Type 1 diabetes is an autoimmune condition resulting in insulin deficiency and eventual loss of pancreatic β cell function requiring lifelong insulin therapy. Since the discovery of insulin more than 100 years ago, vast advances in treatments have improved care for many people with type 1 diabetes. Ongoing research on the genetics and immunology of type 1 diabetes and on interventions to ...
Type 1 diabetes
Type 1 diabetes articles from across Nature Portfolio. Type 1 diabetes (also known as diabetes mellitus) is an autoimmune disease in which immune cells attack and destroy the insulin-producing ...
Type 1 diabetes
Abstract. Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and ...
Current and future therapies for type 1 diabetes
In its early stage (Stage 1), type 1 diabetes is usually asymptomatic; however, the development of autoimmunity is often detectable in early life, with circulating autoantibodies targeting insulin or other proteins, such as GAD65, insulinoma-associated protein 2 (IA2) or zinc transporter 8 (ZNT8) [].When a large portion of the beta cell mass has become dysfunctional or lost, asymptomatic ...
Type 1 diabetes mellitus: much progress, many opportunities
The SEARCH for Diabetes in Youth study in the United States found a 1.4% per year increase in T1D incidence from 2002 to 2012, with an unexpected increase in Hispanic youths (14). This increase in the United States is similar to the gradual worldwide annual increase in T1D incidence over the past 30 years.
Type 1 diabetes
Type 1 diabetes mellitus affects 8.5 million people globally and is characterized by autoimmune destruction of pancreatic β cells. This Review discusses cell replacement therapies for T1DM and ...
Global incidence, prevalence, and mortality of type 1 diabetes in 2021
The burden of type 1 diabetes in 2021 is vast and is expected to increase rapidly, especially in resource-limited countries. Most incident and prevalent cases are adults. The substantial missing prevalence highlights the premature mortality of type 1 diabetes and an opportunity to save and extend lives of people with type 1 diabetes. Our new model, which will be made publicly available as the ...
Type 1 diabetes mellitus: a brave new world
Hummel, S. et al. Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation. Diabetologia 66 , 1633-1642 (2023).
PDF Type 1 diabetes
Type 1 diabetes. Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced knowledge related to the pathophysiology of the disease, including interactions between genetic, immune, and environmental contributions, and major ...
Defining a cure for type 1 diabetes: a call to action
This year (2021), the diabetes community celebrates the centennial discovery of insulin replacement therapy, which has been a lifesaver for millions of patients with type 1 diabetes. Although improvements in diabetes management have become increasingly efficient in controlling glycaemia by use of synthetic insulins, glucose-sensing devices, insulin pumps, and most recently hybrid closed-loop ...
How stem cells could fix type 1 diabetes
Liam Drew. Encapsulated stem cell-derived islets could shield β cells from the immune system. Credit: Ref. 8. Insulin has been one of the most transformative discoveries in medicine. The ...
Diagnosis and treatment of type 1 diabetes at the dawn of the
Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes patient cohort is highly heterogeneous, with individuals presenting with disease at different stages and severities, arising from distinct etiologies, and overlaying varied genetic ...
Recent Advances
Type 1 diabetes is caused by an autoimmune attack of insulin-producing beta-cells. While genetics and the environment are known to play important roles, the underlying factors explaining why the immune system mistakenly recognize beta-cells as foreign is not known. Now, Dr. Delong has discovered a potential explanation.
Type 1 Diabetes Mellitus: A Review on Advances and Challenges in
1. Introduction. Diabetes mellitus (DM) is the most common group of metabolic disorders affecting the population in 2021. More than one in ten people, which is equivalent to 537 million people worldwide, suffers from DM, making it one of the biggest health problems in the world [].It encloses a group of chronic disorders that can be split into four major categories: type 1 diabetes mellitus ...
Changing the landscape for type 1 diabetes: the first step to
Over several decades, studies have described the progression of autoimmune diabetes, from the first appearance of autoantibodies until, and after, the diagnosis of clinical disease with hyperglycaemia and insulin dependence. Despite the improved management of type 1 diabetes with exogenous insulin, most patients do not meet clinical glycaemic goals, and diabetes remains an important medical ...
Type 1 Research Highlights
Type 1 Research Highlights. While the Association's priority is to improve the lives of all people affected by diabetes, type 1 diabetes is a critical focus of the organization. In fact, in 2016, 37 percent of our research budget was dedicated to projects relevant to type 1 diabetes. Read more about the critical research made possible by the ...
Type 1 Diabetes Research At-a-Glance
The burden of type 1 diabetes remains substantial, and more research is needed to improve the lives of people with type 1 diabetes and to find a cure. To this end, ADA-funded research continues to drive progress by funding research projects topics spanning technology, islet transplantation, immunology, improving transition to self-management ...
Diabetes self-management education programs: Results from a nationwide
Objective Population-based studies of reasons for not participating in diabetes self-management education (DSME) are scarce. Therefore, we investigated what sociodemographic and disease-related factors are associated with participation in DSME, the reasons for not participating in DSME and how participants evaluate DSME. Research design and methods We used data from the nationwide survey ...
Type 1 diabetes mellitus: much progress, many opportunities
Diabetes Control Complications Trial (DCCT)/Epidemiology of Diabetes Interventions Complications (EDIC) Study Research Group. Mortality in type 1 diabetes in the DCCT/EDIC versus the general population. Diabetes Care. 2016;39(8):1378-1383. View this article via: PubMed Google Scholar.
Type 1 diabetes: from the dream of automated insulin delivery to a
By 1974, a portable closed-loop artificial pancreas, which used algorithms on a computer consol to deliver intravenous insulin, was used successfully to treat diabetic ketoacidosis and coma in ...
Weekly insulin injection as effective as daily injections in type 1 and
A once-weekly injection of insulin is as effective as daily injections for blood sugar management in both type 1 and type 2 diabetes mellitus (T1DM/T2DM), studies have suggested. In a phase 3, non-inferior study, published in The Lancet on 10 September 2024, 692 adults with T1DM were randomly assigned to receive either once-weekly insulin efsitora […]
Type 1 Diabetes
Definition and Description. Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which destruction of pancreatic β-cells causes insulin deficiency which leads to hyperglycemia and a tendency to ketoacidosis. 1 Excesses glucose levels must be managed by exogenous insulin injections several times a day. 2 Patients with T1D constitute 5-10% of all people with diabetes, the remainder ...
Type 1 diabetes
The incidence of type 1 diabetes is not uniform worldwide. Type 1 diabetes is the third most common chronic disease of childhood, affecting one in 300 children, and there is consensus that the incidence is increasing. 1 In the USA, epidemiological data on the incidence in adults are still scarce and suggest that 0·55% of adults in the USA have type 1 diabetes (based on self-reporting methods ...
Increased Rates of Hospitalized Children with Type 1 and Type 2
The incidence of newly diagnosed diabetes continues to rise in the United States, with a 4.8% increase per year for type 2 diabetes (T2DM) and a 1.9% increase per year for type 1 diabetes mellitus (T1DM) between 2002 and 2015 . The effect of SARS-CoV-2 infection may increase incidence of diabetes in children.
Prevalence and incidence of type 1 diabetes in the world: a systematic
Finally, articles that received a score of 4 on checklist questions were included in the research, 128 articles earned 4 score, 46 articles earned 3 score and 19 articles earned 2 score and finally their data were extracted to perform the meta-analysis. ... In type 1 diabetes incidence, the heterogeneity between studies in the meta-analysis was ...
Transcultural adaptation and validation of Persian Version of Patient
Background The Patient Assessment of Chronic Illness Care (PACIC-5As) questionnaire has been designed to evaluate the healthcare experiences of individuals with chronic diseases such as diabetes. Older adults are at higher risk for diabetes and its associated complications. The aim of this study was transcultural adaptation and evaluation of the validity and reliability of the PACIC-5As ...
Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is an autoimmune disease that leads to the destruction of insulin-producing pancreatic beta cells. There is heterogeneity in the metabolic, genetic, and immunogenetic characteristics of T1D and age-related differences, requiring a personalized approach for each individual. Loss of insulin secretion can occur quickly or gradually. Residual insulin production ...
COMMENTS
Type 1 diabetes is an autoimmune condition resulting in insulin deficiency and eventual loss of pancreatic β cell function requiring lifelong insulin therapy. Since the discovery of insulin more than 100 years ago, vast advances in treatments have improved care for many people with type 1 diabetes. Ongoing research on the genetics and immunology of type 1 diabetes and on interventions to ...
Type 1 diabetes articles from across Nature Portfolio. Type 1 diabetes (also known as diabetes mellitus) is an autoimmune disease in which immune cells attack and destroy the insulin-producing ...
Abstract. Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and ...
In its early stage (Stage 1), type 1 diabetes is usually asymptomatic; however, the development of autoimmunity is often detectable in early life, with circulating autoantibodies targeting insulin or other proteins, such as GAD65, insulinoma-associated protein 2 (IA2) or zinc transporter 8 (ZNT8) [].When a large portion of the beta cell mass has become dysfunctional or lost, asymptomatic ...
The SEARCH for Diabetes in Youth study in the United States found a 1.4% per year increase in T1D incidence from 2002 to 2012, with an unexpected increase in Hispanic youths (14). This increase in the United States is similar to the gradual worldwide annual increase in T1D incidence over the past 30 years.
Type 1 diabetes mellitus affects 8.5 million people globally and is characterized by autoimmune destruction of pancreatic β cells. This Review discusses cell replacement therapies for T1DM and ...
The burden of type 1 diabetes in 2021 is vast and is expected to increase rapidly, especially in resource-limited countries. Most incident and prevalent cases are adults. The substantial missing prevalence highlights the premature mortality of type 1 diabetes and an opportunity to save and extend lives of people with type 1 diabetes. Our new model, which will be made publicly available as the ...
Hummel, S. et al. Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation. Diabetologia 66 , 1633-1642 (2023).
Type 1 diabetes. Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced knowledge related to the pathophysiology of the disease, including interactions between genetic, immune, and environmental contributions, and major ...
This year (2021), the diabetes community celebrates the centennial discovery of insulin replacement therapy, which has been a lifesaver for millions of patients with type 1 diabetes. Although improvements in diabetes management have become increasingly efficient in controlling glycaemia by use of synthetic insulins, glucose-sensing devices, insulin pumps, and most recently hybrid closed-loop ...
Liam Drew. Encapsulated stem cell-derived islets could shield β cells from the immune system. Credit: Ref. 8. Insulin has been one of the most transformative discoveries in medicine. The ...
Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes patient cohort is highly heterogeneous, with individuals presenting with disease at different stages and severities, arising from distinct etiologies, and overlaying varied genetic ...
Type 1 diabetes is caused by an autoimmune attack of insulin-producing beta-cells. While genetics and the environment are known to play important roles, the underlying factors explaining why the immune system mistakenly recognize beta-cells as foreign is not known. Now, Dr. Delong has discovered a potential explanation.
1. Introduction. Diabetes mellitus (DM) is the most common group of metabolic disorders affecting the population in 2021. More than one in ten people, which is equivalent to 537 million people worldwide, suffers from DM, making it one of the biggest health problems in the world [].It encloses a group of chronic disorders that can be split into four major categories: type 1 diabetes mellitus ...
Over several decades, studies have described the progression of autoimmune diabetes, from the first appearance of autoantibodies until, and after, the diagnosis of clinical disease with hyperglycaemia and insulin dependence. Despite the improved management of type 1 diabetes with exogenous insulin, most patients do not meet clinical glycaemic goals, and diabetes remains an important medical ...
Type 1 Research Highlights. While the Association's priority is to improve the lives of all people affected by diabetes, type 1 diabetes is a critical focus of the organization. In fact, in 2016, 37 percent of our research budget was dedicated to projects relevant to type 1 diabetes. Read more about the critical research made possible by the ...
The burden of type 1 diabetes remains substantial, and more research is needed to improve the lives of people with type 1 diabetes and to find a cure. To this end, ADA-funded research continues to drive progress by funding research projects topics spanning technology, islet transplantation, immunology, improving transition to self-management ...
Objective Population-based studies of reasons for not participating in diabetes self-management education (DSME) are scarce. Therefore, we investigated what sociodemographic and disease-related factors are associated with participation in DSME, the reasons for not participating in DSME and how participants evaluate DSME. Research design and methods We used data from the nationwide survey ...
Diabetes Control Complications Trial (DCCT)/Epidemiology of Diabetes Interventions Complications (EDIC) Study Research Group. Mortality in type 1 diabetes in the DCCT/EDIC versus the general population. Diabetes Care. 2016;39(8):1378-1383. View this article via: PubMed Google Scholar.
By 1974, a portable closed-loop artificial pancreas, which used algorithms on a computer consol to deliver intravenous insulin, was used successfully to treat diabetic ketoacidosis and coma in ...
A once-weekly injection of insulin is as effective as daily injections for blood sugar management in both type 1 and type 2 diabetes mellitus (T1DM/T2DM), studies have suggested. In a phase 3, non-inferior study, published in The Lancet on 10 September 2024, 692 adults with T1DM were randomly assigned to receive either once-weekly insulin efsitora […]
Definition and Description. Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which destruction of pancreatic β-cells causes insulin deficiency which leads to hyperglycemia and a tendency to ketoacidosis. 1 Excesses glucose levels must be managed by exogenous insulin injections several times a day. 2 Patients with T1D constitute 5-10% of all people with diabetes, the remainder ...
The incidence of type 1 diabetes is not uniform worldwide. Type 1 diabetes is the third most common chronic disease of childhood, affecting one in 300 children, and there is consensus that the incidence is increasing. 1 In the USA, epidemiological data on the incidence in adults are still scarce and suggest that 0·55% of adults in the USA have type 1 diabetes (based on self-reporting methods ...
The incidence of newly diagnosed diabetes continues to rise in the United States, with a 4.8% increase per year for type 2 diabetes (T2DM) and a 1.9% increase per year for type 1 diabetes mellitus (T1DM) between 2002 and 2015 . The effect of SARS-CoV-2 infection may increase incidence of diabetes in children.
Finally, articles that received a score of 4 on checklist questions were included in the research, 128 articles earned 4 score, 46 articles earned 3 score and 19 articles earned 2 score and finally their data were extracted to perform the meta-analysis. ... In type 1 diabetes incidence, the heterogeneity between studies in the meta-analysis was ...
Background The Patient Assessment of Chronic Illness Care (PACIC-5As) questionnaire has been designed to evaluate the healthcare experiences of individuals with chronic diseases such as diabetes. Older adults are at higher risk for diabetes and its associated complications. The aim of this study was transcultural adaptation and evaluation of the validity and reliability of the PACIC-5As ...
Type 1 diabetes mellitus (T1D) is an autoimmune disease that leads to the destruction of insulin-producing pancreatic beta cells. There is heterogeneity in the metabolic, genetic, and immunogenetic characteristics of T1D and age-related differences, requiring a personalized approach for each individual. Loss of insulin secretion can occur quickly or gradually. Residual insulin production ...