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COMMENTS

  1. 1869: DNA First Isolated

    1869: DNA First Isolated. Friedrich Miescher isolates DNA for the first time. Miescher, a Swiss scientist, wanted to study the chemistry of cells. He chose to study white blood cells, which are abundant in pus, and were abundantly available to him in bandages from a hospital near his university. Miescher isolated a material rich in phosphorus ...

  2. Friedrich Miescher

    Friedrich Miescher (born August 13, 1844, Basel, Switzerland—died August 26, 1895, Davos) was a Swiss student of cell metabolism and the discoverer of nucleic acids. In 1869, while working under Ernst Hoppe-Seyler at the University of Tübingen , Miescher discovered a substance containing both phosphorus and nitrogen in the nuclei of white ...

  3. Friedrich Miescher

    Johannes Friedrich Miescher (13 August 1844 - 26 August 1895) was a Swiss physician and biologist. He was the first scientist to isolate nucleic acid in 1869. Miescher also identified protamine and made several other discoveries.. Miescher had isolated various phosphate-rich chemicals, which he called nuclein (now nucleic acids), from the nuclei of white blood cells in Felix Hoppe-Seyler's ...

  4. Friedrich Miescher and the discovery of DNA

    Initially, Miescher tried to isolate the cells for his experiments from lymph nodes, but it was difficult to purify the lymphocytes and impossible to obtain sufficient quantities for analysis (Miescher, 1869a).On Hoppe-Seyler's suggestion, Miescher changed to examining leucocytes and obtained the cells for his experiments from the pus on fresh surgical bandages, which he collected from the ...

  5. Discovering DNA: Friedrich Miescher and the early years of ...

    In the winter of 1868/9 the young Swiss doctor Friedrich Miescher, working in the laboratory of Felix Hoppe-Seyler at the University of Tübingen, performed experiments on the chemical composition of leukocytes that lead to the discovery of DNA. In his experiments, Miescher noticed a precipitate of an unknown substance, which he characterised ...

  6. Discovery of the Function of DNA Resulted from the Work of ...

    Interestingly, Miescher did not believe that nuclein was the carrier of hereditary information, because he thought it lacked the variability necessary to account for the incredible diversity among ...

  7. Friedrich Miescher and the discovery of DNA

    Friedrich Miescher and the discovery of DNA Dev Biol. 2005 Feb 15;278(2):274-88. doi: 10.1016/j.ydbio.2004.11.028. ... MacLeod, and McCarty showing that DNA is the hereditary material. Within 10 years of their experiments, Watson and Crick deciphered its structure and yet another decade on the genetic code was cracked. However, the DNA story ...

  8. Friedrich Miescher :: DNA from the Beginning

    Friedrich's father was a physician and taught pathological anatomy; Friedrich's uncle, Wilhelm His, was a well-known embryologist. Miescher was an excellent student despite his shyness and a hearing handicap. Miescher initially wanted to be a priest, but his father opposed the idea and Miescher entered medical school.

  9. Friedrich Miescher: The Pioneer of Nucleic Acid Discovery

    In the annals of scientific history, the name Friedrich Miescher stands tall as a pioneer whose groundbreaking work paved the way for our understanding of the fundamental building blocks of life - nucleic acids. Miescher's fascination with the human body and its composition drove him to study medicine at the University of Basel. However, his ...

  10. Discovering DNA: Friedrich Miescher and the early years of nucleic acid

    Abstract. In the winter of 1868/9 the young Swiss doctor Friedrich Miescher, working in the laboratory of Felix Hoppe-Seyler at the University of Tübingen, performed experiments on the chemical composition of leukocytes that lead to the discovery of DNA. In his experiments, Miescher noticed a precipitate of an unknown substance, which he ...

  11. From discovering to understanding: Friedrich Miescher's attempts to

    Between 1868 and 1869, Miescher worked at the University of Tübingen in Germany (Figs 2,3), where he tried to understand the chemical basis of life.A crucial difference in his approach compared with earlier attempts was that he worked with isolated cells—leukocytes that he obtained from pus—and later purified nuclei, rather than whole organs or tissues.

  12. Discovering DNA: Friedrich Miescher and the early years of ...

    In the winter of 1868/9 the young Swiss doctor Friedrich Miescher, working in the laboratory of Felix Hoppe-Seyler at the University of Tübingen, performed experiments on the chemical composition of leukocytes that lead to the discovery of DNA. In his experiments, Miescher noticed a precipitate of an unknown substance, which he characterised further. Its properties during the isolation ...

  13. (PDF) Discovering DNA: Friedrich Miescher and the early years of

    Abstract and Figures. In the winter of 1868/9 the young Swiss doctor Friedrich Miescher, working in the laboratory of Felix Hoppe-Seyler at the University of Tübingen, performed experiments on ...

  14. Discovery of DNA Double Helix: Watson and Crick

    Rather, DNA was first identified in the late 1860s by Swiss chemist Friedrich Miescher. Then, in the decades following Miescher's discovery, other scientists--notably, Phoebus Levene and Erwin ...

  15. Before Watson and Crick in 1953 Came Friedrich Miescher in 1869

    Abstract. In 1869, the young Swiss biochemist Friedrich Miescher discovered the molecule we now refer to as DNA, developing techniques for its extraction. In this paper we explain why his name is all but forgotten, and his role in the history of genetics is mostly overlooked. We focus on the role of national rivalries and disciplinary turf wars ...

  16. Classic experiments: DNA as the genetic material

    Apparently DNA was discovered by a Swiss scientist named Friedrich Miescher in 1868, so almost contemperaneous to Mendel. Doesn't roll off the English speaking tongue as easily as Watson and Crick (or Franklin). Also, part of the experiment might be even grosser than fruit flies.

  17. Miescher and the isolation of DNA :: CSHL DNA Learning Center

    If you are the server administrator, please consult the Ruffle wiki for help. In 1869, Fredrich Miescher was the first to isolate DNA. 16356. Biography 15: Friedrich Miesche (1844-1895) 16062. Friedrich Miescher. 16344. Gallery 15: Friedrich Miescher's laboratory in 1879. 15672.

  18. 14.1: Historical Basis of Modern Understanding

    DNA was first isolated from white blood cells by Friedrich Miescher, who called it nuclein because it was isolated from nuclei. Frederick Griffith's experiments with strains of Streptococcus pneumoniae provided the first hint that DNA may be the transforming principle. Avery, MacLeod, and McCarty proved that DNA is required for the ...

  19. DNA translated: Friedrich Miescher's discovery of nuclein in its

    In 1871, the Swiss physiological chemist Friedrich Miescher published the results of a detailed chemical analysis of pus cells, in which he showed that the nuclei of these cells contained a hitherto unknown phosphorus-rich chemical which he named 'nuclein' for its specific localisation. ... Also Gregor Mendel: Experiments on Plant Hybrids ...

  20. Friedrich Miescher's Discovery in the Historiography of ...

    In 1869, Johann Friedrich Miescher discovered a new substance in the nucleus of living cells. The substance, which he called nuclein, is now known as DNA, yet both Miescher's name and his theoretical ideas about nuclein are all but forgotten. This paper traces the trajectory of Miescher's reception in the historiography of genetics.

  21. Friedrich Miescher's Discovery in the Historiography of ...

    In 1869, Johann Friedrich Miescher discovered a new substance in the nucleus of living cells. The substance, which he called nuclein, is now known as DNA, yet both Miescher's name and his theoretical ideas about nuclein are all but forgotten. This paper traces the trajectory of Miescher's reception in the historiography of genetics. To his critics, Miescher was a "contaminator," whose ...

  22. Friedrich Miescher, the Man Who Discovered Dna

    FRIEDRICH MIESCHER, THE MAN WHO DISCOVERED DNA. A historical account of the discovery of DNA in 1869, including a brief biography of Miescher and a description of the historical context and of the emergence of research schools. It concentrates on the experiments Miescher carried out for the isolation, analysis and characterization of DNA.

  23. | A glass vial containing DNA purified by Friedrich Miescher from

    Friedrich Miescher's attempts to uncover the function of DNA. | Switzerland and 19th Century History | ResearchGate, the professional network for scientists. Fig 4 - uploaded by Ralf Dahm Content ...