multiple system atrophy case study

Short abstract. Multiple system atrophy (MSA) is the most rapidly progressive neurodegenerative disorder among the various types of synucleinopathies. The cause of MSA remains unknown, but it can involve the extrapyramidal system, the pyramidal system, the autonomic nerves and the cerebellum. The main clinical manifestations are Parkinson's ...

This is a practical guide to diagnosing and managing multiple system atrophy (MSA). We explain the newly published Movement Disorders Society Consensus Diagnostic Criteria, which include new 'Clinically Established MSA' and 'Possible Prodromal MSA' categories, hopefully reducing time to diagnosis. We then highlight the key clinical features of MSA to aid diagnosis. We include a list of ...

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by varying degrees of autonomic failure (AF), ... Kostev K. Pre-diagnostic presentations of multiple system atrophy case control study in a primary care dataset. Parkinsonism Relat Disord. 2022; 99:101-104. ...

Introduction. Multiple system atrophy (MSA) is an adult-onset sporadic neurodegenerative disease clinically defined by severe autonomic failure, parkinsonism, and/or cerebellar ataxia [].It is the second most common neurodegenerative movement disorder with an average annual incidence rate of 3 per 100000 person-years after Parkinson's disease (PD) [].

Method: The case study follows a 61-year-old, right handed, Caucasian male with 16 years of education. He was diagnosed in 2014 with Multiple System Atrophy with dominant cerebellar features, and requested a neuropsychological assessment to determine his current neurocognitive status.

Multiple system atrophy (MSA) is the most rapidly progressive neurodegenerative disorder among the various types of synucleinopathies. The cause of MSA remains unknown, but it can involve the extrapyramidal system, the pyramidal system, the autonomic nerves and the cerebellum. The main clinical manifestations are Parkinson's symptoms ...

Background Multiple system atrophy (MSA) is a progressive, incurable, life-threatening neurodegenerative disease uniquely characterized by the risk of sudden death, which makes diagnosis delivery challenging for neurologists. Empirical studies on breaking a diagnosis of MSA are scarce, with no guidelines currently established. This study aimed to investigate neurologists' current practices ...

Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with parkinsonism or cerebellar ataxia. Over the past 5 years, substantial progress has been achieved in understanding the pathogenesis of the disease. Important insights into the epidemiology and genetics of MSA have confirmed the key pathogenic ...

Multiple system atrophy (MSA) is a rare neurodegenerative disorder that pathologically involves the basal ganglia, brainstem, cerebellum, and spinal cord; it cl ... Vidailhet M, Elbaz A, et al. Risk factors of multiple system atrophy: a case-control study in French patients. Mov Disord 2008; 23:797. Wakabayashi K, Kawachi I, Toyoshima Y ...

Abstract. Clinical diagnosis of multiple system atrophy is challenging and many patients with Lewy body disease (i.e. Parkinson's disease or dementia with Lewy bodies) or progressive supranuclear palsy are misdiagnosed as having multiple system atrophy in life. The clinical records of 203 patients with a clinical diagnosis of multiple system ...

Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study PLoS One. 2015 Aug ... Background: Multiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the ...

Introduction. Multiple system atrophy (MSA) is an uncommon progressive neurodegenerative disorder that usually affects adults and is more predominance in men with male-to-female ratio of 1.3: 1 [ 1, 2 ]. Due to its rareness with an annual incidence of 0.1-3.0 per 100,000, depending on age and geographic region [ 3, 4 ], MSA is usually missed on ...

Multiple system atrophy (MSA) is a rare, rapidly progressive, and invariably fatal neurological condition characterized by autonomic failure, parkinsonism, and/or ataxia. There is no available treatment to slow or halt disease progression. A Study of BHV-3241 in Subjects with Multiple System Atrophy Jacksonville, FL.

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by a combination of symptoms that affect both the central nervous system (which controls how a person moves), and the autonomic nervous system, which controls involuntary functions such as blood pressure or digestion. MSA was formerly known as Shy-Drager syndrome, olivopontocerebellar atrophy (OCPA), or ...

Abstract. Aim: There is increasing evidence suggesting that vitamins may play important roles in the pathogenesis of multiple system atrophy (MSA). The purpose of this study was to detect the changes of serum vitamin levels and investigate their correlation with disease severity in MSA patients. Methods: In this cross-sectional study, 244 MSA ...

Parkinsonism and dysautonomia with anti-CV2/CRMP5 associated paraneoplastic neurological syndromes mimicking multiple system atrophy: a case report. BMC Neurol 2021; 21:408. 10.1186/s12883 ... A systematic review and recommendations by the movement disorder society multiple system atrophy study group. Mov Disord Clin Pract 2020; 7:750-62. 10. ...

242324 Introduction: Multiple System Atrophy (MSA) is a neurodegenerative disease marked by prominent alpha-synuclein (α-Syn) pathology, leading to multisystem neuronal and oligodendrocyte degeneration. Clinically, it presents with severe autonomic failure, orthostatic hypotension, neurogenic bladder, and sexual dysfunction, coupled with parkinsonism and/or ataxia.

Multiple system atrophy (MSA) is a unifying term that brings together a group of rare, fatal neurodegenerative syndromes that used to be referred to as olivopon ... Vidal JS, Vidailhet M, Elbaz A, et al. Risk factors of multiple system atrophy: a case-control study in French patients. Mov Disord 2008; 23:797. Wenning GK, Stefanova N, Jellinger ...

The epidemiology of multiple system atrophy (MSA) is scarcely known, and risk factors have not been definitely identified. We investigated the effect of family history for neurodegenerative diseases and environmental factors on MSA risk in a multicentric case-control study. A total of 73 MSA patients (42 men, 31 women; age, 64.3 +/- 8.1 years ...

1. Introduction. Multiple system atrophy (MSA) is a rare but fatal neurodegenerative disease characterized by variable combination of progressive autonomic dysfunction, Parkinson's symptoms, cerebellar ataxia, and pyramidal tract dysfunction, with a mean survival time being 6-10 years from symptom onset (Wenning et al., 2013; Coon et al., 2015; Foubert-Samier et al., 2020).

Retrograde axonal neurodegeneration along the visual pathway—either direct or trans-synaptic—has already been demonstrated in multiple sclerosis (MS), as well as in compressive, vascular, or posttraumatic lesions of the visual pathway. Optical coherence tomography (OCT) can noninvasively track macular and optic nerve changes occurring as a result of this phenomenon. Our paper aimed to ...

The WHO Urban Health team is seeking examples that illustrate a strategic approach to urban health. Collectively, these case studies are intended to show that such an approach can originate and flourish from a wide range of entry points across a diversity of sectors and scales, while leveraging many different combinations of partners. The case studies will inform a major global WHO report on ...

[Purpose] The aim of this case study is to reconsider the method for preventing orthostatic hypotension in multiple system atrophy. [Participant and Methods] The case was that of a 70-year-old female with multiple system atrophy who experienced frequent falls and orthostatic hypotension. An orthosta …

Multiple system atrophy (MSA) is a fatal and still poorly understood degenerative movement disorder that is characterised by autonomic failure, cerebellar ataxia, and parkinsonism in various combinations. ... which includes retrospective case series with incomplete recordings of clinical features and single-centre studies that are limited by ...

Objective Cognition has been reported to be involved in patients with multiple system atrophy (MSA), although initially it was considered an exclusion in the diagnosis of MSA. ... Materials and methods This was a prospective, case-control, single-center study. Thirty patients with MSA (20 MSA-C (cerebellar variant) and 10 MSA-P (Parkinsonian ...