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Why You Should Take Care of Your Body and Health

  • Why It Matters
  • Eat a Balanced Diet

Make Sleep a Priority

  • Stay Active
  • Avoid Harmful Substances
  • Manage Your Stress

Taking care of your physical body is good for your mental health. The mind and body interact and influence one another in complex ways. Physical illness can make managing your mental well-being more difficult. Stress, lack of energy, poor sleep, and other problems can also take a toll on how you feel mentally.

This article discusses why you should take care of your body and how it can support your mental health. It also explores what you can do to take better care of yourself.

Why Taking Care of Your Body is Good for Mental Health

There are a number of reasons why taking care of your body is good for your mental health:

  • Health problems affect functioning : Health problems, even minor ones, can interfere with or even overshadow other aspects of your life. Even relatively minor health issues such as aches, pains, lethargy, and indigestion take a toll on your happiness and stress levels.
  • Poor health habits can add stress to your life : They also play a role in how well you are able to cope with stress. The stress that comes from poor health is significant.
  • Poor health interferes with daily living : Health challenges also affect other areas of your life. Health problems can make daily tasks more challenging, create financial stress, and even jeopardize your ability to earn a living.
  • Stress can worsen health : Stress itself can exacerbate health issues from the common cold to more serious conditions and diseases, so maintaining healthy habits can pay off in the long run. This article looks at some healthy habits that have a positive impact on your life.

One way to improve your ability to cope with stress and feel better is to make a commitment to healthier habits .

Press Play for Advice On Creating Good Habits

This episode of The Verywell Mind Podcast , featuring Katy Milkman, PhD, shares how to build healthy habits to create lasting change. Click below to listen now.

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Eat a Balanced Diet for the Right Reasons

Rather than eating right solely for the promise of looking better in your jeans, you should also make a commitment to eating foods that will boost your energy levels and keep your system running smoothly. This is because what you eat can not only impact your short-term and long-term health, it can affect your stress levels.

It's much harder to cope with stress if you are hungry or malnourished. Hunger can make you more emotionally reactive to stressors, leaving you irritable or even angry in the face of minor daily annoyances. Watching what you eat can be a stress management tool as well as a health preserver.

Another reason it's a good idea to maintain a healthy diet is that your diet can have an effect on your mood.

While the effects of an unhealthy diet are cumulative and become more apparent in the long-term, you are also less likely to feel well in the short-term if you are eating a diet heavy on sugar-laden, fatty, or nutritionally empty foods.

Some of the more immediate effects poor diet include feeling:

Eating well has important long-term consequences, but it may also help you feel more energetic and optimistic in the short-term as well.

Stay Motivated

If you remind yourself that what you eat now will affect how you feel in the coming hours, it may be easier to stick to a healthy diet.

Sleep can have a serious impact on your overall health and well-being. Poor sleep can take a toll on mental health and contribute to problems including anxiety, depression, mood changes, and behavior changes.

Make a commitment to get enough sleep at night. If you haven't gotten adequate sleep, you may be less productive, less mentally sharp, and otherwise more prone to the effects of stress.

Some good habits that can help:

  • Try to get a full eight hours of sleep each night
  • Avoid caffeine after 2 pm
  • Avoid eating foods in the evening that might disrupt your sleep
  • Go to bed at the same time each night; wake up at the same time each morning
  • Create a restful sleep environment; make sure your bed is comfortable and keep the room at an optimal temperature for sleeping (between 60 and 67 degrees Fahrenheit)
  • Adopt a calming technique such as meditation to help yourself relax each night before bed

You may be surprised by how much less stressed you feel when you're not tired. Following good strategies can help if you have trouble getting quality sleep when stressed . Not only will you sleep better, but you’ll feel better all day.

Find a Fitness Habit That Works for You

We've all heard the advice to eat right and exercise. However, it can be difficult to fit in workouts around a busy schedule, particularly when you're feeling exhausted from stress. 

Make It a Habit

One effective strategy for making fitness a regular part of your life is to build an exercise habit around your other habits—either attach a workout to your morning routine, or your lunchtime habits, or make it a regular part of your evening.  

If you make a morning jog part of your getting-ready-for-work routine, for example, it is much more likely to happen than if you wait until you feel like jogging and happen to have a free half-hour, especially if you lead a busy life like most of us and are tired at the end of the day. 

Do Something You Enjoy

Another important way to make exercise easier is to choose an activity that you actually enjoy. Some examples include walking while listening to an audiobook or attending a class at your gym where good music drives up your energy level. Finding an activity that you enjoy means that you are more likely to stick with it.

Find a form of exercise that you'd like to do and then find a time when you can make it work with your schedule.

Watch What You Put Into Your Body

Avoid putting unhealthy substances into your body; nicotine, excess alcohol, and even excessive caffeine can take a toll on your health in the long run, but also make you feel lousy overall in your day-to-day life.

In addition to watching what you put into your body, it also helps if you can avoid allowing toxic thinking patterns from exacerbating your stress levels as well.  Find healthier ways to manage stress, and you'll enjoy double health and stress management benefits .

Find Ways to Manage Your Stress

Stress is an inevitable part of life, but it can take a serious toll on your mind and body if it gets out of hand. Excessive stress is linked to a number of serious health ailments, including cardiovascular disease, diabetes, obesity, and ulcers.

Stress management strategies that can help include:

  • Practicing mindfulness : Mindfulness is an approach that involves focusing more on the here and now instead of fretting over the past or future. It can help increase your self-awareness and improve your ability to handle the daily challenges life throws your way.
  • Utilize stress management techniques : Incorporate a variety of stress management tactics into your life, such as deep breathing, guided imagery, and positive self-talk. Making these a habit can help you combat stress in the short-term, as well as later down the road.
  • Eat a balanced diet : A poor diet can exacerbate the negative effects of stress. Instead of reaching for high-sugar snacks or fast food meals, focused on following a balanced diet that incorporates fruits and vegetables, lean proteins, and complex carbohydrates. 

Finding ways to manage your stress effectively can minimize the negative impact on your health. It can also be beneficial for your emotional health and reduce your risk of burnout, anxiety, and depression.

A Word From Verywell

These are three important ways to take care of your body that you may not naturally think of as stress relievers. If you set goals to make these ideas a reality in your life, not only will you feel the difference immediately, but you will also see results in multiple areas of your life in the coming weeks and months. Few habits come without effort, but these three can make a significant impact on your life, and are well worth the effort.

Yaribeygi H, Panahi Y, Sahraei H, Johnston TP, Sahebkar A. The impact of stress on body function: A review .  EXCLI J . 2017;16:1057–1072. doi:10.17179/excli2017-480

Yau YH, Potenza MN. Stress and eating behaviors .  Minerva Endocrinol . 2013;38(3):255–267.

Owen L, Corfe B. The role of diet and nutrition on mental health and wellbeing . Proc Nutr Soc . 2017;76(4):425-426. doi:10.1017/S0029665117001057

Breymeyer KL, Lampe JW, McGregor BA, Neuhouser ML. Subjective mood and energy levels of healthy weight and overweight/obese healthy adults on high-and low-glycemic load experimental diets .  Appetite . 2016;107:253–259. doi:10.1016/j.appet.2016.08.008

Choi DW, Chun SY, Lee SA, Han KT, Park EC. Association between sleep duration and perceived stress: salaried worker in circumstances of high workload .  Int J Environ Res Public Health . 2018;15(4):796. doi:10.3390/ijerph15040796

Gardner B, Lally P, Wardle J. Making health habitual: the psychology of 'habit-formation' and general practice .  Br J Gen Pract . 2012;62(605):664–666. doi:10.3399/bjgp12X659466

Rood L, Roelofs J, Bögels SM, Alloy LB. Dimensions of negative thinking and the relations with symptoms of depression and anxiety in children and adolescents .  Cognit Ther Res . 2010;34(4):333–342. doi:10.1007/s10608-009-9261-y

Kriakous SA, Elliott KA, Lamers C, Owen R. The effectiveness of mindfulness-based stress reduction on the psychological functioning of healthcare professionals: a systematic review .  Mindfulness (N Y) . 2021;12(1):1-28. doi:10.1007/s12671-020-01500-9

Nguyen-rodriguez ST, Unger JB, Spruijt-metz D.  Psychological determinants of emotional eating in adolescence.   Eat Disord . 2009;17(3):211-24. doi:10.1080/10640260902848543

By Elizabeth Scott, PhD Elizabeth Scott, PhD is an author, workshop leader, educator, and award-winning blogger on stress management, positive psychology, relationships, and emotional wellbeing.

Become a Writer Today

Essays About Health: Top 5 Examples and 7 Prompts

Almost everyone would agree that health is the most important thing in life. Check out our guide on writing essays about health.

The concept of health is simple. It is the condition where you are well and free from disease or illness. When we are healthy, we are happier, more productive, and able to live a full life. There are many types of health, each helping us to survive and excel in different areas of our life, including physical, mental, spiritual, and emotional health.

In the same ways, there are different ways to stay healthy, such as exercise, socialization, and self-care. These areas of health may not all be equally important, but each of them plays a vital role in making us the best versions of ourselves we can be. You might also find our medical words list helpful.

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5 Top Essay Examples

1. essay on how to keep healthy by diwakar sharma, 2. what it’s like living with depression: a personal essay by nadine dirks, 3. the advantages of eating healthy food by lindsay boyers.

  • 4.  A Helping Hand: An Essay On The Importance Of Mental Health Parity by Sydney Waltner

5. ​​Stop Trying to be Happy: Improving Your Emotional Health by Jacquelynn Lyon

7 prompts for essays about health, 1. what is the most important type of health, 2. do television and video games negatively impact mental , 3. freedom and public health, 4. how can you live a healthier life, 5. what causes depression, 6. mental health and eating disorders, 7. is “spiritual health” really necessary.

“I think there is no use in earning money in such a way that denies our health. Money is not important than health as it cannot return health and fitness back once we are ill. Thus health is always preferred over money as good health keeps us happy and free from various health issues. If we are healthy we can earn whole life but can’t earn if the health gets deteriorated.”

Sharma discusses the importance of health and ways to stay healthy, including eating nutritious food, drinking water, keeping a good sleep schedule, and exercising. In addition, he notes that it is essential to prioritize your health; do not work too hard or chase money to the extent that it affects your health negatively. You can also check out these articles about cancer .

“I was pleasantly surprised when—after around three weeks—I started feeling results. My intense feeling of overwhelming sadness and hopelessness slowly started to lift and the fears I had about not feeling like myself dissipated. I had worried I would feel less like myself on fluoxetine, but instead for the first time, in a long time—I felt more like myself and able to function throughout the day. Receiving treatment and building healthy coping mechanisms has allowed me to continue to function, even when a depressive episode hits.”

Depression is one of the first things people think of concerning mental health. In her essay, Dirks reflects on her experiences with depression, recalling her feelings of hopelessness and sadness, putting her in a dull, lethargic mood. However, she got help by going to a doctor and starting medication and therapy. Dirks also lists down a few symptoms of depression, warning readers to get help if they are experiencing a number of them.

“A healthful diet is just as good for your brain as the rest of your body. Unhealthy foods are linked to a range of neurological problems. Certain nutrient deficiencies increasing the risk of depression. Other nutrients, like potassium, actually involved in brain cell function. A varied, healthful diet keeps your brain functioning properly, and it can promote good mental health as well.”

Boyers discusses some benefits of healthy eating, such as weight control, reduced risk of diabetes and cancer, and better brain function- an unhealthy diet is linked to neurological problems. She gives readers tips on what they should and should not eat in huge quantities, saying to avoid sugary foods and drinks while eating lean meat, fruits, vegetables, and whole grains. You might also be interested in these essays about nursing and essays about obesity .

4.   A Helping Hand: An Essay On The Importance Of Mental Health Parity by Sydney Waltner

“For three years I was one of those people hiding my illness. I was quietly suffering from depression and an eating disorder. My whole day revolved around my eating disorder and hiding it from everyone. This caused a lot of sadness, anger, and loneliness. I not only hid it from others, but I also tried to hide it from myself. I tried to convince myself that nothing was wrong because I did not fully understand what was happening.  I did not know what was making me hurt myself and why I could not stop.”

Waltner writes her essay about the importance of mental health and how it can also affect one’s physical health. She recalls her experiences with hiding her depression and eating disorder; they led to her immense suffering, but her parents discovered her illness before it was too late. She is grateful for how her life is now and encourages others to break the stigma around mental health issues and speak up if something is wrong with them. 

“Beautiful people, smart people, funny people, leaders, lawyers, engineers, professional clowns, everyone you’ve ever looked up to — they have suffered in their lives, and probably will continue to suffer at some point.”

The obsession with making yourself happy will forever have you either not valuing the present or will lead to despair when you do find it — and it’s still not enough. This cycle of self-abuse, dissatisfaction, and emotional isolation can paralyze us, hinder our actions, and mar our self-perception.

Lyon reflects on something she discovered in her first year of college: that it’s fine if you’re not always happy. She says that society’s pressure for everyone to be positive and happy 100% of the time is detrimental to many people’s emotional and mental health. As a result, she gives readers tips on being happy in a “healthier” way: happiness should not be forced, and you should not constantly compare yourself to others. 

Essays About Health: What is the most important type of health?

There are many types of health, each playing an essential role in helping us live well. If you were to pick one, which do you believe is the most important? You can choose mental well-being, physical well-being, or spiritual well-being. Use your personal experiences in defending your choice; be sure to support your stance with sufficient details. 

For a strong argumentative essay, write about the correlation between “screen time” or video games and television with mental health. Are they that bad for people’s mental health? Perhaps they are good for the mental health of some people. Research this topic and support your response with credible sources- there is no wrong answer as long as it is well-defended. For an interesting piece, conduct interviews to gather information.

Due to the COVID-19 pandemic, many argue that some freedoms must be given up for the greater good. These include mask mandates, vaccine mandates, and stay-at-home orders. Write about whether or not public health should be prioritized over “individual liberty” and why. If so, to what extent? Answer this question in your own words for a compelling argument.

Essays About Health: How can you live a healthier life?

Like many of our cited essay examples above, you can write your essay on how to stay healthy. Give your readers some mental, physical, or social guidelines for being healthier, and explain why they are important. You can even do a more well-rounded guide; give a few tips for each type of health if you wish. 

As stated previously, a prevalent health issue is depression, which can stem from various factors. Look into the different causes of depression and explain how they lead to depression. In this essay, you can share your research on social factors, economic factors, and health conditions that can make a person more susceptible to depression. As this is a medical-related topic, use credible sources for your research. 

Many believe there is a correlation between mental health and obesity, anorexia, and bulimia—research how mental health issues can cause these issues or vice versa, depending on what you find. In your essay, explain the link between mental health issues and eating disorders and how they can affect each other.

Essays About Health: Is “Spiritual Health” really necessary?

A type of health commonly listed is spiritual health, which many religious people value. Should it be classified as something different? Many believe the components of “spiritual health” already fall under mental, social, emotional, and social health, so there is no need to classify it as something different. Reflect on this issue and discuss your stance. 

For help with this topic, read our guide explaining “what is persuasive writing ?”

If you’re stuck picking an essay topic, check out our guide on how to write essays about depression .

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  • Health Essay

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Essay on Health

Health is wealth. It is the biggest asset we need every day to meet our goals. Previously, the definition of health was the proper functioning of our organ systems. As time passed, the definition has changed. Good health now includes the physical and mental wellbeing of a person. A person can be physically fit but mentally disturbed due to the circumstances he is facing. The same can happen when someone is suffering from physical illnesses but is mentally strong.

Maintaining proper health is the prime concern these days. This is a competitive era where you cannot stop. The moment you stop you will be replaced by a better option. This is why everyone is running in the rat race without thinking about their wellbeing. The compromise towards health becomes a costly affair later. In the cities, people are more affected by mental issues than physical ones. Constant stress and lack of physical activities contribute to the problem.

Proper health comprises many factors. It includes good food, proper routine, good sleeping habits, and eating habits. Apart from these personal traits, many external factors also control your wellbeing. People in the villages stay physically stronger due to freshness in the air, physical activities, and good food. People in the urban areas, on the contrary, prefer eating unhealthy food, lack physical agility, and cannot handle mental stress properly. In the same context, urban settlement has a better lifestyle and healthcare system. Considering all the components, a person needs to give equal importance to the factors and maintain a balance.

The elements of good health are physical and mental fitness. If both are maintained, a person will enjoy a better life. How can we achieve that state? First, we have to find out the factors influencing physical health. We have to learn about the lifestyle diseases that affect our health and check the ways to avoid or manage them. Secondly, we have to eat good food and maintain a healthy diet. We need to ensure a balanced diet and good food habits to provide nutrition to our systems. In this aspect, we also have to find out the harmful foods we generally prefer eating and avoid them. Regular exercise is the third most important part of good health. When we are physically active, our muscles remain functional. We get hurt very less and also recover faster. We can also maintain our body balance better when we are involved in physical activities.

The next phase is mental happiness. What makes us happy? One can be happy watching TV all the time. Sitting on the couch all day long can also make someone happy but is it a healthy choice? This type of lifestyle choice should be immediately avoided. Choosing a sedentary lifestyle is nothing but an invitation to different diseases. The current urban population is suffering from weight-related issues. Being overweight also makes the situation worse. Lifestyle diseases such as high blood pressure, diabetes, cholesterol elevation, cardiovascular diseases, etc develop at a young age.

We also need to make better choices when it comes to mental health. Playing sports with your buddies will help you relax and de-stress. You can also take a walk in the park and enjoy the greenery. Avoid spending more time on the screen and try to develop a hobby that suits you. In this way, you can become happier and stay healthier.

A person also needs to choose better social factors to remain free from social stigmas. Cognitive health and social health are equally important. Adding more stress will not be the solution. Keep exercising physically and mentally to remain fit and enjoy good health and longer life. Make your home stress-free with good habits and keep everyone healthy.

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FAQs on Health Essay

1. What are the Prime Elements Included in Good Health?

The prime elements of good health are physical health, mental health, and social health. A person needs to be physically and mentally fit in a healthy environment. A society should also provide a healthy environment for a person to remain stress-free and enjoy life. Even though an ideal society does not exist, it is not hard to maintain a healthy lifestyle. These elements should be maintained properly to enjoy overall good health and survive in this competitive world. It is important for all family members.

2. Why is Mental Health Also Important?

Previously mental health was not included in the wellbeing of a person. Now that we have found the direct relationship between physical and mental health, it has become an important factor to consider. Many surveys suggest that mental health in a society is ignored. People are less happy when they are surrounded by many responsibilities. Circumstances also make a person sad and mentally unfit. If this continues, a person becomes prone to physical illnesses. Stress is a major reason for mental illnesses. By educating people regarding the importance of mental health, we can avoid such issues.

3. How Can We Teach the Importance of Mental Wellness?

From the very beginning, kids should be taught what mental wellness is. They should play outside, have fun with their friends, play, get hurt, and learn what mental wellness is. Adults also need proper guidance to understand the importance of mental wellness. They should maintain a proper balance between personal and professional life to stay happy. All we have to remember is an individual laughing might not be happy. We need to find out what makes us happy.

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Essay on Good Health And Well Being

Students are often asked to write an essay on Good Health And Well Being in their schools and colleges. And if you’re also looking for the same, we have created 100-word, 250-word, and 500-word essays on the topic.

Let’s take a look…

100 Words Essay on Good Health And Well Being

Importance of good health.

Good health is like a treasure. When we are healthy, we can play, learn, and enjoy life. It means our body is working well, and we feel good. To stay healthy, eating fruits and vegetables, drinking water, and sleeping enough is important.

Exercise for Fitness

Moving our bodies makes us strong and fit. Playing sports, dancing, or even walking are great exercises. They keep our heart healthy and muscles strong. Exercise also makes us feel happy by releasing special chemicals in our brain.

Mental Health Matters

Being healthy is not just about the body but also the mind. Talking about feelings, being kind, and having fun with friends keep our mind healthy. It’s important to relax and not worry too much.

Preventing Sickness

Staying away from germs helps us not get sick. Washing hands, keeping clean, and getting vaccines are ways to fight germs. When we don’t feel well, seeing a doctor is a good idea to get better.

250 Words Essay on Good Health And Well Being

What is good health.

Good health means your body is working as it should, without any pain or illness. When you have good health, you can run, jump, play, and do all your school work without feeling tired or sick. It’s like a well-oiled machine that runs smoothly.

Why is Well Being Important?

Well being is about feeling happy and calm in your mind. It’s just as important as having a strong body. When your well being is taken care of, you can make friends, learn new things, and handle stress better.

Eating Right for Health

To stay healthy, you need to eat all kinds of foods like fruits, vegetables, grains, proteins, and dairy. Imagine your plate as a rainbow, with lots of different colors. Each color gives you different vitamins and minerals to keep you healthy.

Staying Active

Our bodies are made to move. Playing sports, dancing, or just walking your dog are great ways to stay active. When you move, your heart gets stronger and you can concentrate better in class.

Resting Well

Sleep is just as important as food and exercise. When you sleep, your body fixes any damage and gets ready for a new day. Try to get 8-10 hours of sleep each night.

Keeping a Happy Mind

Taking care of your feelings is part of well being. Talk to friends, write in a journal, or draw pictures to express yourself. This keeps your mind happy and healthy.

Good health and well being are about balancing eating right, staying active, resting well, and keeping a happy mind. When all these pieces fit together, you can play, learn, and grow every day.

500 Words Essay on Good Health And Well Being

Good health means your body is working as it should, without any pain or sickness. When you have good health, you can play, work, and learn better. Imagine a car that runs smoothly because all its parts are in top shape. Your body is just like that car. When all parts of your body are in good condition, you feel great and are ready to take on the world.

Why is Good Health Important?

Eating right.

Eating right is like putting the best fuel in a car. Fruits, vegetables, grains, protein, and dairy products are all good for you. They give you the energy to run, think, and do all the things you love. Eating too much junk food is like putting sand in your car’s gas tank. It can make you feel tired and can lead to sickness.

Being active is another way to keep your body in good shape. Think of it as taking your car for a drive instead of leaving it in the garage all the time. When you run, play sports, or dance, you make your muscles stronger and your heart happy. Exercise can also make you feel happier because it releases chemicals in your brain that make you feel good.

Rest and Relaxation

Staying clean.

Keeping your body clean is like keeping your car shiny and free of dirt. Bathing, brushing your teeth, and washing your hands can keep germs away. Germs are tiny bugs that can make you sick, so it’s important to stay clean to keep them at bay.

Seeing the Doctor

Going to the doctor is like taking your car for a check-up. The doctor makes sure everything is working right and can help prevent sickness or catch it early when it’s easier to treat. Getting vaccinated is one way doctors help protect you from serious illnesses.

Good health is not just about your body but also about your feelings and thoughts. Talking about your feelings, staying positive, and spending time with friends and family can keep your mind healthy. Just like your body, your mind needs to be taken care of to feel good.

Good health and well-being are like a treasure that helps you live a happy and full life. By eating right, staying active, getting enough rest, keeping clean, seeing the doctor, and taking care of your feelings, you can keep this treasure shining. Remember, taking care of your health is one of the most important things you can do every day!

That’s it! I hope the essay helped you.

If you’re looking for more, here are essays on other interesting topics:

Happy studying!

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Importance Of Good Health (Essay Sample)

The importance of good health.

Good health is crucial to everything we do in our everyday lives. The importance of good health can be clearly seen in how we function as human beings in the daily tasks that define our functionality in the society. Without good health, we are not able to reach our individual potentials and this can hinder us from achieving our personal goals in the social environment that we exist in.

True enough, defining good health moves beyond the physical sense; it also includes emotional and mental. Good health means the different aspects of well-being which are mold together. For one individual to function properly, he or she should be physically fit, as well as emotionally and mentally. Having one missing aspect in an individual’s health can have heavy implications for an individual.

In both home and work, health is also required in building social relationships. If we are unfit to build these connections, it can imply that we are depriving ourselves of social stimulation that can help in improving our outlook and disposition in everything we do. In most cases, it can be said that good health can be equated to an individual’s self-actualization. An individual who is actualized has a nurtured sense of disposition in the society which makes him or her energetic enough to be able to face different problems that may arise during the day.

At home, good health can be a collective concept for it is also crucial to the well-being of the good family. This means that healthy relationships are required in order for families to function as a single organ. Without health, relationships may fall apart and this can bring both short term and long term damages to how we perceive life.

In professional spaces, health is crucial in dealing with different workplace situations and conflicts. If one is unfit in any of the mentioned aspects above, this can heavily affect how an individual becomes productive in the workplace. Of course, good health can be equated to productivity in this context and without it, more conflicts may arise that may be very hard to deal with.

To achieve good health, we as individuals should know the proper steps in nurturing ourselves. We need to be able to take care of ourselves in order to also know how to take care of others around us. Knowing to take the right meals, eat healthy food, drink the proper amount of water and get the right hours of sleep are the basic things that we need to master. What comes after these are more self-conscious steps that can then nourish our mental health; this includes engaging in healthy discussions with other people as well as lively and productive conversations that nurture positivity instead of negativity. We must also know to surround ourselves with the right people so that we can continue living a live with less worry. Emotional health is also a crucial part in us, as individuals. This is heavily influenced by our social relationships as well as our perception of our own selves. The key in ensuring emotional health is to always gauge our feelings and knowing how to deal with it properly. If our own selves are not capable of ensuring all these, seeking our family, friends and even professionals for help is always an option. The worst thing that we can do is to deprive ourselves of good health. Good health is not a myth; it is something that we can rally achieve as long as we put our minds in it and as long as we remember how to properly value ourselves. All it takes is the right perception of our self-worth and some self-esteem.

essay the importance of health

essay the importance of health

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Essay on Health: Long and Short Essay Samples

essay the importance of health

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  • Jan 3, 2024

Essay on Health

Essay on Health:

Earlier, health was said to be the ability of the body to function well. However, as the time evolved, the definition of health also evolved. Health now, is the primary thing after which everything else follows. When you maintain good health, everything else falls into place.

In an era where our lives are increasingly busy and filled with demands, our health often takes a backseat. Yet, it’s a priceless asset that influences every facet of our existence. In this blog, we explore the multifaceted realm of health through both long and short essay samples. From the significance of well-being to practical tips for maintaining it, our collection delves into the critical role health plays in our lives. Join us in this journey to uncover the secrets of a healthier, happier life.

Table of Contents

  • 1 How to Maintain Health?
  • 2 Importance of Health
  • 3 Sample Essay On Health in 150 Words
  • 4 Sample Essay On Health in 300 Words

Must Read: Essay On My Hobby

How to Maintain Health?

Good health is above wealth. Listed foundational practices below promote overall health and well-being: 

  • Balanced Diet: Eat a variety of nutrient-rich foods, including fruits, vegetables, lean proteins, and whole grains. Do not miss out on the essential nutrients; take each of them in appropriate quantities.
  • Regular Exercise: Exercise daily, it can be for a duration of 15-30 minutes. Include strength training exercises to build muscle and bone strength.
  • Adequate Sleep: Prioritize 7-9 hours of quality sleep per night to support physical and mental well-being. Instead of using your phone, go to sleep at a reasonable hour.
  • Stress Management: Practice stress-reduction techniques such as meditation, yoga, or mindfulness.
  • Regular Check-ups: Schedule routine health check-ups and screenings to detect and address health issues early.
  • Avoid Bad Habits: Do not smoke or drink as it has serious harmful consequences.

Importance of Health

Good health is vital for a fulfilling life. It empowers us to thrive physically, mentally, and emotionally, enhancing overall well-being. It is of paramount importance for various reasons:

  • Quality of Life: It directly affects our daily lives, enabling us to enjoy activities, work, and relationships to the fullest.
  • Productivity: Good health enhances productivity, allowing us to perform better in our personal and professional endeavours.
  • Longevity: It contributes to a longer life, giving us more time to pursue our goals and spend time with loved ones.
  • Financial Well-being: Staying healthy reduces medical expenses and the economic burden of illness.
  • Emotional Well-being: Physical health is closely linked to mental well-being, impacting our mood, stress levels, and overall happiness.
  • Preventive Care: Maintaining health through regular check-ups can detect and address potential issues before they become severe.
  • Community and Societal Impact: Healthy individuals contribute to stronger communities and societies, reducing the strain on healthcare systems and promoting collective well-being.

Must Read: Essay On Human Rights

Sample Essay On Health in 150 Words

Maintaining good health is dependent on a lot of factors. Those factors range from the air you breathe to the type of people you choose to spend your time with. Health has a lot of components which carry equal importance. If even one of them is missing, a person cannot be completely healthy.Health is our most valuable asset. It encompasses physical, mental, and emotional well-being, shaping our lives profoundly. A healthy lifestyle, characterized by a balanced diet, regular exercise, and adequate sleep, is essential. It not only prevents diseases but also boosts energy and productivity.

Mental health is equally vital, requiring stress management and emotional support. Regular check-ups aid in early disease detection, increasing the chances of successful treatment. Good health influences longevity and quality of life, allowing us to pursue dreams and cherish moments with loved ones. It also eases the financial burden associated with illness. Ultimately, health is the foundation of a joyful, fulfilling existence, and its importance cannot be overstated.

Sample Essay On Health in 300 Words

Health is undeniably one of the most precious aspects of life. It encompasses not only the absence of diseases but also the presence of physical, mental, and emotional well-being. In this essay, we will explore the multifaceted importance of health in our lives.

Firstly, physical health is the cornerstone of our existence. It allows us to carry out daily activities, pursue our passions, and engage with the world. Maintaining good physical health involves a balanced diet that provides essential nutrients, regular exercise to keep our bodies fit, and sufficient rest to recuperate. A healthy lifestyle not only prevents various ailments but also increases our vitality and longevity.

There is this stigma that surrounds mental health. People should take mental illnesses seriously. In order to be completely fit, one must also be mentally fit. When people completely discredit mental illnesses, it makes a negative impact. Hence, we should treat mental health the same as physical health.

Mental health is equally crucial. It involves managing stress, maintaining emotional stability, and seeking support when needed. Neglecting mental health can lead to conditions like anxiety and depression, which can have a profound impact on the quality of life.

Moreover, health plays a pivotal role in determining our overall happiness and well-being. When we are in good health, we have the energy and enthusiasm to enjoy life to the fullest. It enhances our productivity at work or in our daily chores, leading to a sense of accomplishment.

Furthermore, health is closely linked to financial stability. Medical expenses associated with illness can be overwhelming. Maintaining good health through preventive measures and regular check-ups can save us from substantial healthcare costs.

In conclusion, health is not merely the absence of illness; it is the presence of physical, mental, and emotional well-being. 

Related Reads:

Good health enables a fulfilling life, impacting longevity, happiness, and productivity.

Health encompasses physical, mental, and emotional well-being, signifying a state of overall vitality.

Health is evident in energy levels, a balanced mind, regular check-ups, and the ability to engage in daily activities with ease.

This brings us to the end of our blog on Essay on Health. Hope you find this information useful. For more information on such informative topics for your school, visit our essay writing and follow Leverage Edu.

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Student Essays

Essay On Health For Students

Essay on Health & Importance of Health for Students

Health is defined as the state of body physically and mentally sound. Health is the prime source of happiness and comfort.

Read Following Best written Essays on Topic Health, importance & benefits of maintaining good health in life. These short and long essays are quite helpful for children & students.

Essay on Health, Importance, Benefits For Children & Students

Good health is the key to success. It is something which is neither bought nor sold but maintained. One who is sick remains confined to the bed.

Someone has said that there are four layers of energies which gives us good health, they are physical energy, mental energy, emotional energy and spiritual energy.

Benefits & Importance of Good Health

Health is very important aspect of life. The physical and mental well being of a person plays an important role in the life of a person. The absence of disease in life makes man able to achieve desired aims and objectives.

Related Post:   Paragraphs on Health is Wealth

One can work effectively when he enjoys good health. An unhealthy person can’t enjoy life, can’t ho out and can’t embrace the beauty of nature fully. Those who are healthy can work better and can excel in life. One who doesn’t have good health, he owns nothing.

There are numerous benefits of good health, only a healthy person can bounce back difficult experiences, can adapt to adversity, can achieve balance in life and can feel secure and safe.

How to Stay Healthy

To maintain good health one must go to bed early and wake up early. As it is said that early to bed, early to rise makes a man healthy, wealthy and wise. One who aspire to be healthy, he must adopt this law.

Regular exercise also help maintain good health. Exercise keeps body fit and makes man active and energetic. Jogging and walking are good forms of exercise.

One must eat balanced diet, hygienic food and keep oneself neat and clean. Cleanliness is the sign of good health. To enjoy a healthy life we must reduce the level of consumption of fast foods because fast foods are not good for health. Eat green leafy vegetables and fresh fruits to keep yourself healthy.

Those who smoke and drink excessively, they must reduce or quit smoking and drinking because these are injurious to health. In this modern period people have become more mechanized and are dependent on machines, they have become inactive and lazy. Physical activity is very for good health.

The surroundings and environment plays an important role in maintaining good health, one must keep the surroundings clean. Pollution free environment is the sole panacea of avoiding diseases.

Related Post:  Health is Wealth Speech For Students

Many diseases are caused by environmental pollution therefore it is necessary to keep environment clean and hygiene before maintaining good health. Nowadays temperatures of earth is increasing due to green house gases, one must avoid being out during noon time specially in summer season because sun’s harmful rays can cause skin cancer and can damage skin. Specially keep children indoor while sun is hot.

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Improving and Maintaining Health and Well-Being Essay

  • To find inspiration for your paper and overcome writer’s block
  • As a source of information (ensure proper referencing)
  • As a template for you assignment

Personal Insights and Relevance to Nursing Practice

Advantage for the future practice, relevance to mnc code, reference list.

Improving and maintaining health and well-being is the personal responsibility of each person. There might be a lot of activities one could undertake to contribute to their physical and mental health. For this reflective account, I chose interventions such as yoga and dieting. Yoga is popular among those who monitor the body’s health and strive for inner harmony. This ancient practice is based on a combination of physical and spiritual development. Yoga practitioners strive to grow spiritually and improve themselves. On the other hand, the body’s most vital instinct—necessary for maintaining life—is the gratification of hunger. First of all, the food we eat creates the cells and tissues that make up our entire body. Second, eating provides the body with the energy it needs to function. Therefore, dieting—including what we eat, in what quantity, when, and how—depends on our health.

Doing yoga and healthy dieting have impacted my understanding of my health. I have noticed that when I implement these activities as habits in my life, I start to notice improvements in my well-being. I feel more energetic, and my immune system becomes stronger. People who practice yoga regularly note that the body becomes strong and flexible, and the mind calms down. When I do yoga every day for a minimum of one hour, I feel my muscles are stronger, and my mind is calmer. In the past, I have suffered from high-stress levels; however, yoga helps me manage such problems. The main thing in yoga is to find harmony and peace of mind, and breathing exercises and meditation techniques help with this. Improved well-being, a sense of peace, and a positive attitude – are just a small part of the positive results that yoga gave me.

It is believed that the improvement of the body is a complex result of physical activity, mental work, and lifestyle changes. Yoga classes positively affect all life support systems of the body. The study held by Hilcove et al. (2021) showed that yoga interventions helped nurses decrease and control stress levels. Mindfulness-based yoga helped participants to prevent burnout and positively affected their well-being (Hilcove, 2021). Another research that was handled by Kim (2020) revealed that yoga intervention helps to solve problems with “chronic nonspecific lower back pain in nursing practice” (Kim, 2020, p. 7). Yoga programs are considered a tool for managing pain relief (Kim, 2020). The activity is also beneficial for the lungs and is recommended for patients with lung problems (Kupershmidt and Barnable, 2019). Thus, implementing yoga intervention in the nursing practice is an effective way to improve the well-being of the patients.

After the first weeks of classes, you can feel the benefits of yoga. It allows you to learn to feel your body, manage your health, and expand the range of your lungs. At the same time, the physical activity allows us to see quick results. Classes have practically no contraindications or age and gender restrictions. Initial data and level of preparation do not matter. Now joint lessons with children, couples, and wellness sessions for the older age category are popular. If a beginner pursues not only the goal of losing weight and getting a beautiful body but also accepting himself and his needs, learning to live in harmony with the mind and shell, then yoga will give him this.

Adding healthy dieting to yoga made me see an even bigger positive effect on my well-being. Because yoga aims to teach mindfulness, I have become more conscious of my diet. Drinking more water and cutting out junk helped improve my health conditions. The body needs to consistently consume a variety of nutrients, including proteins, carbs, fats, water, minerals, and vitamins in the right amounts and proportions. The risk of contracting certain diseases increases when specific nutrients are either insufficient or excessive. Healthy eating helps build up mental and physical vitality, enables weight maintenance without harsh restrictions, and aids in the prevention and treatment of diseases. Healthy eating and dieting are an important part of a healthy lifestyle.

Of course, the role of dieting in nursing practice can not be underestimated. Distinct types of patients with different health problems require specific diets. The study provided by Kurnia and Yulia (2021) showed that nutritional education is crucial for patients with diabetes and their families. Food affects the sugar levels in the blood, and thus, people who suffer from diabetes should pay attention to their food choices (Kurnia and Yulia, 2021). Dieting helps control many aspects of the human body and thus plays an important role in patient care. A complex relationship and interdependence exist between substances that enter the body with food. For example, calcium is needed to build and maintain bones. In turn, calcium can be absorbed in the body only in the presence of vitamin D (Riccio and Rossano, 2018). For calcium to function, phosphorus and magnesium are required; they act only in the presence of copper and zinc. Nutrition is one of the important factors of human health that provides adequate growth and development in childhood, high performance of the adult population, and active longevity of the elderly and old people.

The information I have gained from this activity will be useful for my future practice. Now, when I have explored the benefits that yoga and dieting interventions can bring, I will try to implement them when relevant. Nurses are responsible for contributing to the well-being of their patients. That is why it was highly motivational for me to analyze how specific activities affected my health and lifestyle. Moreover, these and many other interventions may demonstrate positive results systematically and properly. A person’s well-being depends on what activity they undertake in their everyday life. Both yoga and dieting interventions showed to have positive results on my health, and I hope it will be the same for my future patients.

This reflective account is relevant to the MNC code and its distinctive themes. Generally, the code includes four themes referred to prioritizing people, practicing effectively, preserving safety, and promoting professionalism and trust (NMC Code, 2022). I want to discuss effective practice and promoting professionalism and trust. For instance, yoga and dieting are related to the ‘practice effectively’ theme. When yoga is practiced regularly, it brings more results for the body and mind. Accordingly, when dieting options are made correctly, they will be more effective and beneficial for the patient’s health. ‘Promote professionalism and trust theme is also connected with the two interventions as patients should trust the process. Health care professionals should educate patients about the efficiency of the activities they implement to be aware of the purpose of these particular interventions.

Kurnia, D. A. and Yulia, Y. (2021) ‘Understanding food selection and dieting patterns: type 2 diabetes mellitus patients and their families.’ International Journal of Endocrinology (Ukraine) , 17(6), 456-458.

Hilcove, K., et. al. (2021) ‘Holistic nursing in practice: Mindfulness-based yoga as an intervention to manage stress and burnout.’ Journal of Holistic Nursing , 39(1), 29-42.

Kim, S. D. (2020) ‘Twelve weeks of yoga for chronic nonspecific lower back pain: a meta-analysis.’ Pain Management Nursing , 21(6), 536-542.

Kupershmidt, S., and Barnable, T. (2019) ‘Definition of a yoga breathing (pranayama) protocol that improves lung function.’ Holistic Nursing Practice , 33(4), 197-203.

Riccio, P., and Rossano, R. (2018) ‘Diet, gut microbiota, and vitamins D+ A in multiple sclerosis.’ Neurotherapeutics , 15(1), 75-91.

NMC Code. (2022) The Nursing and Midwifery Council.

  • Nurse Participation in Policy-Making
  • Nurses’ Participation in Policy Reviews
  • Yoga and Stress Reduction
  • Sugar Substitutes in Keto Dieting
  • The Disconnect Between Tradition and Contemporary Practice in Yoga
  • Quality Outcomes and Reduce Costs in Stroke Care
  • Project Communication in a Nursing Setting
  • Improving Health Care Delivery: Teenage Pregnancy
  • The New Graduate Nurse Residency™ at Merakey
  • Nursing: Working With Aggressive Mentally Ill Patients
  • Chicago (A-D)
  • Chicago (N-B)

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Mental Health Essay

Mental Health Essay

Introduction

Mental health, often overshadowed by its physical counterpart, is an intricate and essential aspect of human existence. It envelops our emotions, psychological state, and social well-being, shaping our thoughts, behaviors, and interactions. With the complexities of modern life—constant connectivity, societal pressures, personal expectations, and the frenzied pace of technological advancements—mental well-being has become increasingly paramount. Historically, conversations around this topic have been hushed, shrouded in stigma and misunderstanding. However, as the curtains of misconception slowly lift, we find ourselves in an era where discussions about mental health are not only welcomed but are also seen as vital. Recognizing and addressing the nuances of our mental state is not merely about managing disorders; it's about understanding the essence of who we are, how we process the world around us, and how we navigate the myriad challenges thrown our way. This essay aims to delve deep into the realm of mental health, shedding light on its importance, the potential consequences of neglect, and the spectrum of mental disorders that many face in silence.

Importance of Mental Health

Mental health plays a pivotal role in determining how individuals think, feel, and act. It influences our decision-making processes, stress management techniques, interpersonal relationships, and even our physical health. A well-tuned mental state boosts productivity, creativity, and the intrinsic sense of self-worth, laying the groundwork for a fulfilling life.

Negative Impact of Mental Health

Neglecting mental health, on the other hand, can lead to severe consequences. Reduced productivity, strained relationships, substance abuse, physical health issues like heart diseases, and even reduced life expectancy are just some of the repercussions of poor mental health. It not only affects the individual in question but also has a ripple effect on their community, workplace, and family.

Mental Disorders: Types and Prevalence

Mental disorders are varied and can range from anxiety and mood disorders like depression and bipolar disorder to more severe conditions such as schizophrenia.

  • Depression: Characterized by persistent sadness, lack of interest in activities, and fatigue.
  • Anxiety Disorders: Encompass conditions like generalized anxiety disorder, panic attacks, and specific phobias.
  • Schizophrenia: A complex disorder affecting a person's ability to think, feel, and behave clearly.

The prevalence of these disorders has been on the rise, underscoring the need for comprehensive mental health initiatives and awareness campaigns.

Understanding Mental Health and Its Importance

Mental health is not merely the absence of disorders but encompasses emotional, psychological, and social well-being. Recognizing the signs of deteriorating mental health, like prolonged sadness, extreme mood fluctuations, or social withdrawal, is crucial. Understanding stems from awareness and education. Societal stigmas surrounding mental health have often deterred individuals from seeking help. Breaking these barriers, fostering open conversations, and ensuring access to mental health care are imperative steps.

Conclusion: Mental Health

Mental health, undeniably, is as significant as physical health, if not more. In an era where the stressors are myriad, from societal pressures to personal challenges, mental resilience and well-being are essential. Investing time and resources into mental health initiatives, and more importantly, nurturing a society that understands, respects, and prioritizes mental health is the need of the hour.

  • World Leaders: Several influential personalities, from celebrities to sports stars, have openly discussed their mental health challenges, shedding light on the universality of these issues and the importance of addressing them.
  • Workplaces: Progressive organizations are now incorporating mental health programs, recognizing the tangible benefits of a mentally healthy workforce, from increased productivity to enhanced creativity.
  • Educational Institutions: Schools and colleges, witnessing the effects of stress and other mental health issues on students, are increasingly integrating counseling services and mental health education in their curriculum.

In weaving through the intricate tapestry of mental health, it becomes evident that it's an area that requires collective attention, understanding, and action.

  Short Essay about Mental Health

Mental health, an integral facet of human well-being, shapes our emotions, decisions, and daily interactions. Just as one would care for a sprained ankle or a fever, our minds too require attention and nurture. In today's bustling world, mental well-being is often put on the back burner, overshadowed by the immediate demands of life. Yet, its impact is pervasive, influencing our productivity, relationships, and overall quality of life.

Sadly, mental health issues have long been stigmatized, seen as a sign of weakness or dismissed as mere mood swings. However, they are as real and significant as any physical ailment. From anxiety to depression, these disorders have touched countless lives, often in silence due to societal taboos.

But change is on the horizon. As awareness grows, conversations are shifting from hushed whispers to open discussions, fostering understanding and support. Institutions, workplaces, and communities are increasingly acknowledging the importance of mental health, implementing programs, and offering resources.

In conclusion, mental health is not a peripheral concern but a central one, crucial to our holistic well-being. It's high time we prioritize it, eliminating stigma and fostering an environment where everyone feels supported in their mental health journey.

Frequently Asked Questions

  • What is the primary focus of a mental health essay?

Answer: The primary focus of a mental health essay is to delve into the intricacies of mental well-being, its significance in our daily lives, the various challenges people face, and the broader societal implications. It aims to shed light on both the psychological and emotional aspects of mental health, often emphasizing the importance of understanding, empathy, and proactive care.

  • How can writing an essay on mental health help raise awareness about its importance?

Answer: Writing an essay on mental health can effectively articulate the nuances and complexities of the topic, making it more accessible to a wider audience. By presenting facts, personal anecdotes, and research, the essay can demystify misconceptions, highlight the prevalence of mental health issues, and underscore the need for destigmatizing discussions around it. An impactful essay can ignite conversations, inspire action, and contribute to a more informed and empathetic society.

  • What are some common topics covered in a mental health essay?

Answer: Common topics in a mental health essay might include the definition and importance of mental health, the connection between mental and physical well-being, various mental disorders and their symptoms, societal stigmas and misconceptions, the impact of modern life on mental health, and the significance of therapy and counseling. It may also delve into personal experiences, case studies, and the broader societal implications of neglecting mental health.

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Health and Fitness Essay for Students and Children

500+ words essay on health and fitness.

We have always heard the word ‘health’ and ‘fitness’. We use it ourselves when we say phrases like ‘health is wealth’ and ‘fitness is the key’. What does the word health really mean? It implies the idea of ‘being well’. We call a person healthy and fit when he/she function well physically as well as mentally.

Health And Fitness Essay

Factors Affecting our Health and Fitness

Good health and fitness is not something which one can achieve entirely on our own. It depends on their physical environment and the quality of food intake. We live in villages, towns, and cities.

In such places, even our physical environment affects our health. Therefore, our social responsibility of pollution-free environment directly affects our health. Our day-to-day habits also determine our fitness level. The quality of food, air, water all helps in building our fitness level.

Role of Nutritious Diet on our Health and Fitness

The first thing about where fitness starts is food. We should take nutritious food. Food rich in protein, vitamins, minerals, and carbohydrates is very essential. Protein is necessary for body growth. Carbohydrates provide the required energy in performing various tasks. Vitamin and minerals help in building bones and boosting our immune system.

However, taking food in uneven quantity is not good for the body. Taking essential nutrients in adequate amount is called a balanced diet. Taking a balanced diet keep body and mind strong and healthy. Good food helps in better sleep, proper brain functioning and healthy body weight.

Include vegetables, fruits, and pulses in daily diet. One must have a three-course meal. Having roughage helps in cleaning inner body organs. Healthy food habit prevents various diseases. Reducing the amount of fat in the diet prevents cholesterol and heart diseases.

Get the huge list of more than 500 Essay Topics and Ideas

Impact of Exercise on our Health

Routine exercise helps improve our muscle power. Exercise helps in good oxygen supply and blood flow throughout the body. Heart and lungs work efficiently. Our bones get strong and joints have the pain free movement.

We should daily spend at least twenty minutes in our exercise. Daily morning walk improves our fitness level. We should avoid strenuous Gym activities. Exercise burns our fat and controls the cholesterol level in the body. Various outdoor games like cricket, football, volleyball, etc keeps our body fit. Regular exercise maintains our body shape.

Meditation, Yoga, and Health

Meditation and yoga are part of our life from ancient time. They not only make us physically fit but mentally strong as well. Meditation improves our concentration level. Our mind gets relaxed and thinking becomes positive.

A healthy mind is key for a healthy body. Yoga makes us stressfree and improves the endurance power of the mind. Yoga controls our blood pressure. With yoga, a strong bond with nature is established. Meditation is considered the best way to fight depression.

A person stays happier when he/she is fit and healthy. A fit and healthy person is less prone to chronic diseases. The healthy mind reacts better in a pressure situation. The self-confidence of a person is increased. Risk of heart failure is reduced drastically. With the increased immunity power body could fight cancerous cells. The intensity of the fracture is decreased with regular exercise.

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Home — Essay Samples — Nursing & Health — Mental Health — The Importance of Mental Health Awareness

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The Importance of Mental Health Awareness

  • Categories: Mental Health Social Isolation Stress Management

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Words: 1622 |

Updated: 4 November, 2023

Words: 1622 | Pages: 4 | 9 min read

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Introduction, mental health awareness, video version, emotional well-being, psychological well‐being, social well-being.

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  • Top of Form Mental Health Myths and Facts https://www.mentalhealth.gov/basics/mental-health-myths-facts
  • Mental Health Care Services by Family Physicians Position Paper. American Academy of Family Physicians Web site. http://www.aafp.org/online/en/home/policy/policies/m/mentalhealthcareservices.htm. Accessed February 11, 2013. [Google Scholar]
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essay the importance of health

  • Open access
  • Published: 19 August 2024

If health organisations and staff engage in research, does healthcare improve? Strengthening the evidence base through systematic reviews

  • Annette Boaz 1 ,
  • Belinda Goodenough 2 ,
  • Stephen Hanney 3 &
  • Bryony Soper 3  

Health Research Policy and Systems volume  22 , Article number:  113 ( 2024 ) Cite this article

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There is an often-held assumption that the engagement of clinicians and healthcare organizations in research improves healthcare performance at various levels. Previous reviews found up to 28 studies suggesting a positive association between the engagement of individuals and healthcare organizations in research and improvements in healthcare performance. The current study sought to provide an update.

We updated our existing published systematic review by again addressing the question: Does research engagement (by clinicians and organizations) improve healthcare performance? The search covered the period 1 January 2012 to March 2024, in two phases. First, the formal updated search ran from 1 January 2012 to 31 May 2020, in any healthcare setting or country and focussed on English language publications. In this phase two searches identified 66 901 records. Later, a further check of key journals and citations to identified papers ran from May 2020 to March 2024. In total, 168 papers progressed to full-text appraisal; 62 were identified for inclusion in the update. Then we combined papers from our original and updated reviews.

In the combined review, the literature is dominated by papers from the United States (50/95) and mostly drawn from the Global North. Papers cover various clinical fields, with more on cancer than any other field; 86 of the 95 papers report positive results, of which 70 are purely positive and 16 positive/mixed, meaning there are some negative elements (i.e. aspects where there is a lack of healthcare improvement) in their findings.

Conclusions

The updated review collates a substantial pool of studies, especially when combined with our original review, which are largely positive in terms of the impact of research engagement on processes of care and patient outcomes. Of the potential engagement mechanisms, the review highlights the important role played by research networks. The review also identifies various papers which consider how far there is a “dose effect” from differing amounts of research engagement. Additional lessons come from analyses of equity issues and negative papers. This review provides further evidence of contributions played by systems level research investments such as research networks on processes of care and patient outcomes.

Peer Review reports

There is an often-held assumption that the engagement of clinicians and healthcare organizations in research improves healthcare performance at various levels. This assumption contributed to policy documents from various health organizations promoting research engagement by healthcare providers as a way of improving healthcare, for example, in the United Kingdom [ 1 , 2 , 3 ]. Therefore, it was believed that policy-makers who make relevant decisions, such as on the allocation of resources for health and health research systems, should have access to evidence on the validity of the assumption. In the United Kingdom, two programmes of the National Institute for Health Research (now called the National Institute for Health and Care Research) (NIHR) decided to commission reviews of the global evidence on this [ 1 , 2 , 3 ].

The wide-ranging brief provided for the second review, which was the original review by the authors of this present paper (published in full as Hanney et al. in 2013 [ 3 ] and more succinctly as Boaz et al. in 2015 [ 2 ]), included the additional aim of conducting a theoretically grounded synthesis to explore the mechanisms by which research engagement might improve healthcare [ 3 ]. The protocol for that study considered pertinent global literature, including on accelerating the adoption of evidence in health systems, and ways to enhance the relevance of the research conducted to the needs of health systems. The final protocol published as part of the Hanney et al. report [ 3 ] then used these ideas to identify possible mechanisms that would be worth analysing to help understand the processes that might be at work when research engagement leads to improved health. Among these was the idea that engaging in conducting research increases the ability and willingness of clinicians to use research findings from the global pool of knowledge, and here the concept of “absorptive capacity” was expected to be useful [ 3 ].

Some analyses focussed on the importance of exploring the relationship between research engagement and improved healthcare to contribute towards understanding of the benefits for healthcare performance in the context of a strong research culture. These papers were reviewed in Australia by Harding et al. in 2017 [ 4 ].

As far as we are aware, these three systematic literature reviews published in the second decade of this century provided the first analyses of the empirical evidence available to support the assumption of improved healthcare from research engagement [ 1 , 2 , 3 , 4 ]. Their differing scopes and approaches are summarized briefly in Table  1 .

All three of the reviews reported some evidence of a positive association between research engagement and healthcare performance, but the available evidence was not mature enough to support statements about causality [ 2 ]. Our review [ 2 , 3 ] had the widest scope of the three, reflecting the broad brief given by our NIHR funder. It included an extensive initial mapping exercise, a formal focussed review, and a wider review which drew on the earlier stages to explore, as noted above, the mechanisms by which research engagement might improve healthcare [ 3 ]. Our review identified 33 papers from 9 countries (15 from the United States), 28 of which reported positive findings [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Even our review concluded, however, that there did not appear to be a well-structured, steadily accumulating body of knowledge about the benefits associated with research engagement.

In the succeeding years, we have identified a continuing and growing interest in this general topic, therefore an updated review seemed desirable to gather more evidence about how far research engagement might lead to improved healthcare and the mechanisms involved. In addition to these general questions, our original review had identified two specific issues that could usefully be considered further. These were research networks as potentially important mechanisms through which research engagement might improve healthcare, and whether greater amounts of research engagement would have a larger beneficial effect. Our original review also covered some aspects of a third issue (health equity) that has subsequently become increasingly important [ 2 , 3 ].

The growing development of research networks has been associated with efforts to move towards more formalized attempts to boost the role of health research systems in accelerating science and facilitating the translation of research into practice [ 2 , 3 ]. However, at the time of our original review, the evidence was still emerging and its availability was heavily skewed by the different timing of the establishment of formal research networks in different countries.

In the United States, various research networks had been set up in the second half of the last century, and most of the early papers on networks and their role came from there [ 2 ]. These networks in the United States are described in the “Glossary of the United States of America and United Kingdom Research Organizations and Networks Discussed in the Papers” (see Additional file 1 ). They include the National Cancer Institute (NCI)-funded Cancer Community Oncology Program (CCOP), established to encourage outreach and improve equity by bringing the advantages of clinical research to cancer patients in their own communities [ 37 ]. In the United Kingdom in contrast, national research networks were not formally created until this century, too late for any potential benefits to patient outcomes to be fully researched and reported prior to our review which started in 2011. However, even in our original review we were aware of concurrent United Kingdom work to measure those outcomes and to improve patient access to clinical research, and identified a need for further evaluations (see Hanney et al. [ 3 ], pp. 48, 83).

Subsequently, we also became increasingly aware of new studies on the effects of the developing research networks, especially in the United Kingdom, and Boaz et al. identified a promising approach in statistical analysis that could help further analysis [ 2 ]. As set out in the Glossary, there have been policy shifts and organizational changes in the United States and the United Kingdom, and there have been further ones elsewhere, which are designed to promote research networks to address the time lag between the production of research and its use in practice, including various efforts to strengthen links between academic centres and community services. There has also been an increasing emphasis, including within research networks, on the potential research contribution of healthcare professionals other than medical professionals.

Our original review had also noted a partly related second issue as worthy of further attention. This is the question of whether the association between research engagement by healthcare providers and improved healthcare outcomes increases with greater amounts of research participation. There was early evidence that it did. This came, in particular, from the 2008 paper by Majumdar et al. [ 26 ] that compared outcomes for patients with angina in hospitals in the United States having a high level of angina research activity with hospitals with low research activity, and those with no research activity. Other papers compared centres with different levels of research activity within a research network [ 23 ]. However, there was little certainty about extent and implications around this issue at that time, although it has become increasingly important with the development of the comprehensive research networks that we summarize in the Glossary. It also has theoretical implications for the exact nature of the association between research engagement and improved healthcare: in our original review we argued that further data on this effect, and on the time an institution was research active, “are needed to provide evidence of causation” (p. 12) [ 2 ].

These findings also have implications for health equity, the third unresolved issue. More outreach by research networks means more access to clinical research and its benefits for more patients. The United States CCOP has been rightly lauded for achieving this [ 37 ], but can that be squared with the emerging finding that higher levels of research participation in specific provider institutions bring greater benefit to the patients in those centres?

Reflection on these uncertainties further strengthened the argument that with all the developments since our original review, it seemed timely in 2020 to revisit this topic to explore and collate what additional understanding had been gained. While conducting the resulting update, we became aware of some more recent developments. A United Kingdom qualitative systematic review was published in 2021 that explored the impact of research activity by healthcare professionals other than medical professionals [ 38 ], and another UK review published in 2023 focussed on research engagement by allied health professionals (AHPs) [ 39 ]. With few exceptions, the papers specifically on nursing and AHPs in these reviews were typically smaller scale than the papers included in our formal review, and/or usually did not include the quantifiable comparisons that featured in most of our included papers. Nevertheless, these reviews usefully illustrate the growing interest in the contribution of these healthcare professionals in countries such as Australia, Canada and the United Kingdom.

In addition, we identified a large-scale study from the United States by Shahian et al. [ 40 ] that was published in 2022 and examined the link between research engagement and improved healthcare performance in 5 major medical fields across 1604 Medicare-participating hospitals. A noticeable facet of the paper by Shahian et al. was their referencing of a large number of papers that we had identified either in our original review, or in the first phase of our updated review [ 40 ].

To ensure our updated review adequately reflected all such developments since May 2020, we conducted a further search in March 2024. The review presented here is based on papers identified in both phases of the updated review, the findings of which are then combined with those from our original review.

Review question

To identify studies, the primary research question used the same approach as Boaz et al. [ 2 , 3 ].

Does research engagement (by clinicians and organizations) improve healthcare performance?

By research engagement, we mean, as in our original review, engagement in research rather than the broader concept of engagement with research, and we are referring to participation in research by healthcare organizations and staff rather than patient participation in trials. Engagement in research is taken to mean, “a deliberate set of intellectual and practical activities undertaken by healthcare staff (including conducting research and playing an active role in the whole research cycle) and organizations (including playing an active role in research networks, partnerships or collaborations)” (p. 2) [ 2 ].

The 2020 decision to complete an update of the previous review [ 2 , 3 ] was informed by a published decision framework for updating systematic reviews [ 41 ]. After completion in 2024 of the comprehensive initial phase of the updated review, including the two searches and considerable subsequent analysis, we recognized, as noted above, that while we had been conducting the review some important further papers had been published. We wanted to incorporate such papers, and so decided to conduct a further search for papers. The design of this final phase (which included a third search) was informed both by the fact that we had already identified a considerable number of papers for the updated review, and by the way new papers in this field were by now much more likely to cite earlier papers, with Shahian et al. [ 40 ] being a prime example. Therefore, we thought it was reasonable to rely to a much greater extent on checking citations to the papers already identified, as explained below.

Search strategy and information sources

Search 1 (update).

The first step in syntax development used the Medline Ovid strategy published by Boaz et al. [ 2 ].

Initial diagnostic testing indicated issues preventing code execution. Due to the syntax comprising several nested terms and Boolean operators, it was rebuilt using recommendations for “single-line” optimization for debugging complex code [ 42 ].

Search 2 (modified)

The syntax for Search 2 was a term modification to capture papers that more explicitly indexed research networks and collaborations. Search 2 necessitated a deeper dive into the full-text content of papers. The decision to search full-text articles reflected observations that the sensitivity of Search 1 was potentially affected by the variable quality (and relevance for our review) of abstracts, a consistent challenge for reviewers [ 43 ]. As a second search also adapted published syntax, the Preferred Reporting Items for Systematic reviews and Meta-Analyses Literature Search—Extension Checklist (PRISMA-S) reporting protocol was followed [ 44 ]. (The full text for search strategies is provided in “Search Strategy and Syntax Sensitivity”; see Additional file 2 ).

Electronic databases

Nine electronic records collections were used in Search 1: Medline (OVID and EBSCO), EMBASE, PsycInfo (OVID and EBSCO), CINAHL, Web of Science, Health Management and Information Consortium and British Nursing Institute. The mix provided parity with previous reviews and mitigated risk of missed papers by combining general and specialized databases. Different interfaces (e.g. OVID, EBSCO) for the same collection were also included to offset variations due to platform [ 45 ]. Grey literature was not searched: these collections failed to uniquely identify papers in previous reviews on this topic. Search 2 was restricted to the Medline EBSCO Full Text records, which was the collection which yielded the highest hit ratio for relevant papers (see Additional file 2 ).

Other sources

Manual and snowball searching were used in three ways. Firstly, a range of search engines (Google Scholar, PubMed, ProQuest Central, Scopus, the Web of Science Cited Reference Search) were used to track citations for (a) prior reviews as whole papers, (b) the individual studies within these reviews and (c) article reference lists. Secondly, key journals that published studies shortlisted in the previous reviews were hand-checked, including: Implementation Science, PLOS One, BMJ Open and BMC Health Services Research. Thirdly, topic experts suggested papers for consideration.

Search 3 (final phase)

As explained above, we subsequently conducted a further search covering May 2020–March 2024. This consisted of: a hand-search of three of the journals in which papers from the first phase of the updated review had been published (Health Research Policy and Systems, Implementation Science and Medical Care); a check of papers in the two reviews published in this period [ 38 , 39 ]; and a check of citations in this period to all the papers identified both in our original review and in the update’s initial phase.

Eligibility criteria

The following limiters were applied:

Timeframe: 1 January 2012 to 20 March 2024 (inclusive of eprint)

Population: Human (any setting)

Language: English (any country)

Paper type: Academic Journals (scholarly works). Conference papers were admitted as flags for accessible peer-reviewed works (e.g. pre-print) or key teams.

Three criteria were defined, guided by definitions from the original review [ 3 ].

Criterion A: study design

Empirical studies using method/s aligned with health services research, including clinical trials, retrospective cohort and survey methods. Studies with only patient reported outcomes (e.g. satisfaction) were excluded.

Criterion B: healthcare performance

Studies must report an outcome indexing performance assessment for a care process or healthcare improvement. The following were excluded: staff-specific reports alone, (e.g. job satisfaction or morale), policy impacts alone (no flow through to healthcare), descriptions of networks without outcomes data.

Criterion C: research engagement

Explicit demonstration of engagement in research including: agenda-setting, conducting research, participation in action research or in networks where the research involvement is noted. This criterion also allowed engagement implicitly through research network membership, even if a specific study was not recorded, but there was a comparison of healthcare between member and non-member settings. More details about examples that were in scope can be found in Hanney et al. [ 3 , p. 2].

Records management

To efficiently manage the export of the large records for the first two searches, Endnote X9 (Clarivate) was used to combine downloads from different databases and discard software detected duplicates. The endnote library was imported into Rayyan, a free multi-collaborator online screening tool [ 46 ]. Study selection procedures for Searches 1 and 2 followed the same screening/eligibility check sequence.

Screening and eligibility/quality checking

In Rayyan, titles were scanned to exclude papers that were irrelevant, did not meet criteria or were non-exact duplicates. Abstracts of retained records were then screened and classified as “include”, “exclude” or “maybe”. A third screening of “maybe” classifications forced a binary coding of “include” or “exclude”, with comment flags on issues. A final records’ sweep with the Rayyan query function checked for misclassified studies. This four-step screening process was completed by a single reviewer (BG).

Full-text for each provisionally included study was uploaded into Rayyan. The initial eligibility check was completed by three experts who were involved in article screening for Hanney et al. [ 3 ]. As a criterion check and to orient reviewers to the Rayyan platform, a practice phase used 10 randomly sampled records. The abstract was the primary source for expert reviewers, with full-text also available. After the practice task and consensus discussion of criteria, a batch of records (alphabet determined) was assigned to each expert reviewer, to rate each paper as “include”, “exclude” or “maybe” (ratings were unblinded). If the rating pair (i.e. B.G. and an expert from the original review) were both “include”, the paper was progressed to full-text appraisal. If there was disagreement, papers rated as “maybe” were reassigned to another expert reviewer for an opinion, and those rated as “exclude” by an expert reviewer were marked for discard. If consensus for a “maybe” paper could not be reached by discussion, it was progressed to a full text appraisal, conducted by a single reviewer (B.G.) using all available information sources and reviewer ratings.

A final review of all potential “includes” was jointly conducted by team members, including a few papers identified by other sources such as continued manual snowballing from key papers. The study selection procedures for Search 3 mirrored this final step, and so consisted of a review of all potential “includes” conducted jointly by team members.

Study quality was assessed using the mixed-methods appraisal tool (MMAT v2018), on a scale of 1 (low) to 5 (high) [ 47 ]. The MMAT accommodated all designs in the paper set. The majority of the papers have a design which fitted into the MMAT category of quantitative non-randomized. All papers scored good to high quality on the five questions in their relevant MMAT subscale. The lower end of ratings (good) was typically due to lack of information in the article, such as whether and/or how confounding factors may have been identified or managed. Quality ratings were not used to exclude papers, but formed part of the discussion about the quality and contribution of the papers.

Data extraction, coding and ethics

As Rayyan is only a screening platform, a data extraction sheet was created in Excel (v2016) for each included paper. A university research ethics committee deemed the project as not requiring formal ethical approval, due to secondary data mining on anonymized aggregated records.

A large and methodologically diverse mix of papers was identified with a range of different outcomes and outcome measures. The papers were combined through a process of critical interpretive synthesis inspired, as in our original review, by the approach outlined by Dixon-Woods et al. [ 48 ]. This involves adopting an iterative approach to refining the research question, searching the literature and defining and applying codes and categories. It enables the generation and development of theory with strong explanatory power and uses relevance as one measure of quality. Following analysis of the papers in the updated review, we collated the results from the updated review with those from our original review to create one combined set of papers for overall analysis.

Figure  1 summarizes the review literature flow. The two formal searches identified 66 901 records, with 68 further papers coming from other sources, including the March 2024 extension. From these, 168 papers progressed to full-text appraisal, and 62 were identified for inclusion [ 40 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 ].

figure 1

Flow diagram for literature search

This review updates the previous review conducted by the team [ 2 ]. Table 2 outlines the 95 papers in our combined review: the 62 additional papers in the updated review along with the 33 papers in our original review. The latter 33 papers are shown in italics in Table  2 , which includes details about the study characteristics of all 95 included papers as well as key dimensions of the findings. To complement Table  2 , brief notes on the development and scope of key United States and United Kingdom research networks/organizations discussed in the papers are provided in the “Glossary of the United States of America and United Kingdom Research Organizations and Networks Discussed in the Papers” (see Additional file 1 ).

Study characteristics

Across the 95 papers, 12 countries are either the location for the research engagement described in a single-country study, or the location from which a multi-country study was led, with one paper led from South Africa having authors from a range of African countries (and Yemen) [ 88 ]. The 12 countries are: United States (50 papers), United Kingdom (17), Canada (7), Spain (5), Germany (4), the Netherlands (3), Australia (2), Denmark (2), South Africa (2), China (1), Finland (1) and Sweden (1).

Cancer was the most common field, with 32/95 papers overall. Next came hospital care in general/multi-field/acute care with 16 papers, cardiovascular/stroke (12), substance use disorder (7), dentistry (3), mental health/psychiatry (3) and obstetrics (3).

Main findings

As presented in Table  2 , the key findings from the combined review are presented in terms of the four pairs of binary options, though inevitably some papers did not neatly fit into one category. The first categorization is in terms of the level of analysis explored in different papers; 23 papers compare clinicians, but 72 compare organizations. There is an even higher proportion in the updated review at the organizational level (50/62, 81%) than in our original review (22/33, 67%).

A total of 86 of the 95 papers report positive results, of which 70 are purely positive and 16 are positive/mixed meaning that there are some key negative elements in their findings, that is, important parts of the analysis where a lack of healthcare improvement is identified. Nine papers are negative, of which four are negative-mixed.

The final two pairs of binary options consider just the 86 positive papers. In total, 37/86 report improved health outcomes in terms of reduced mortality or morbidity. A higher proportion of the positive papers in the updated review (30/58, 52%) than in our original review (7/28, 25%) describe such improved health outcomes. There is a corresponding reduction from three quarters (21/28) to a half (28/58) in the proportion of papers solely describing improved processes in terms such as applying proven interventions.

Finally, in terms of the type of impact, 55/86 of the papers describe research engagement leading to a broader impact on healthcare performance. Broad impacts arise when the improved healthcare goes more widely than just being linked to clinicians or healthcare organizations implementing the findings, or processes, from their own research more rapidly/extensively than do others. When the improved healthcare is linked to the results or processes of their own research, that is categorized as specific impact, which is the case in 31/86 papers. Using these various categories, Fig.  2 outlines the findings from the combined review, alongside the findings from our original review, and the updated review. This highlights various trends in terms of the main findings.

figure 2

Results from Boaz et al. systematic reviews of whether research engagement by health organizations and staff improves healthcare: analysis of original; updated; and combined reviews (and of the 86 positive papers). Green rows (top): original review; Brown rows (middle): updated review; blue rows (bottom): combined review

One further trend in terms of the type of analysis is seen in the 11/95 papers that used bibliometric analysis as an indicator of the extent, and/or quality, of research engagement compared with some measure of the healthcare performance, in terms of processes and/or outcomes [ 30 , 40 , 50 , 51 , 56 , 65 , 76 , 95 , 96 , 97 , 100 ]; 10 of these papers are in the updated review, with just 1 [ 30 ] from our original review. All these 11 papers are positive, but various types of bibliometric analysis are used. The broad categories of academic indicators applied include publication volume [ 95 , 96 ], publication “quality” (for example, as measured by citations) [ 51 ] and a combination of volume and “quality” [ 30 , 40 , 50 , 56 , 65 , 76 , 97 , 100 ]. Of the latter, five relatively small studies suggest that the association with “quality” was stronger than with volume. The bibliometric studies also illustrate the varying levels of analysis at which the included studies in the review are conducted; 4 of the 11 papers compare the academic outputs of clinicians [ 50 , 56 , 96 , 97 ] and 7 make comparisons at an organizational level [ 30 , 40 , 51 , 65 , 76 , 95 , 100 ], focussing variously on academic outputs at ward, department or hospital/trust level.

The combined review allows for a range of issues to be analysed more thoroughly than they had been in our original review. These include issues highlighted in the background such as the role of networks and the “dose effect”. These are examined in turn below, followed by consideration of how far the included studies have addressed various aspects of health equity, and finally an analysis of lessons from the overall portfolio of positive and negative studies.

The role of research networks

The full significance of papers on research networks is seen in the combined review. Using the inclusive definition developed by Laliberte et al. [ 24 ], we have applied the term to various arrangements that, however loosely, give some measure of commonality to the research of multiple healthcare organizations that not only enhance science production, but also share a concern to transfer research findings into clinical practice. About half the papers in the combined review analysed research activity by clinicians or healthcare organizations who were part of research networks of various types.

In the United States, the NCI cancer research networks include the NCI-designated Comprehensive Cancer Centres, the NCI Cooperative Groups and collaborative groups of community hospitals affiliated to the NCI’s CCOP- see the Glossary for its new name. In various ways these networks all include outreach and the engagement of community physicians in their brief; see the Glossary for more details. Their potential was recognized early in the 2005 study by Laliberte et al. [ 24 ] that looked at these networks and concluded that network membership may influence compliance with treatment guidelines, and should therefore be taken into account in predictive models of compliance.

Seven included papers illustrated various aspects of this issue by comparing the processes and outcomes for patients treated at NCI-designated (comprehensive) cancer centres with those treated elsewhere, six of these studies showed better outcomes for patients treated at NCI centres [ 52 , 64 , 80 , 84 , 86 , 106 ], while one paper suggested that despite better processes, patient outcomes were worse at NCI centres. This paper is considered in the section on negative papers below [ 81 ]. Of the positive papers, Paulson et al. showed how the NCI designation was “associated with lower risk of postoperative death and improved long-term survival” (p. 675) [ 86 ], identified possible factors such as better adherence to guidelines, and demonstrated that the better outcomes at NCI-designated centres remained even when compared with non-NCI designated centres with a similar high volume of cases [ 86 ]. Wolfson et al. identified the requirements that underpin the positive association between high-quality research and high-quality care [ 106 ]. These included the mandate NCI centres have to “lead clinical trials, exchange ideas, disseminate findings” (p. 3892), which showed how the centres could act as part of a network. Wolfson et al. continued: “The NCI operates on the belief that a culture of discovery, scientific excellence, transdisciplinary research, and collaboration yields tangible benefits extending far beyond the generation of new knowledge” [ 106 ].

Building on Laliberte et al. [ 24 ], Carpenter et al. demonstrated an association between CCOP membership and accelerated innovation adoption but added the important codicil that it was not possible to “definitively ascertain whether there is a direct causal relationship between the two” [ 54 ].

Improved healthcare has also been associated with membership of the United States practice-based research networks (PBRNs). These networks cover family practice/primary care, dentistry, mental health and substance abuse. Like the CCOP and its affiliates, PBRNs involve practising clinicians in the community who conduct research. The combined review includes seven PBRN papers covering primary care and dentistry, all of which are positive [ 32 , 36 , 66 , 78 , 83 , 92 , 108 ] and one of which describes an international dental PBRN led from the United States that includes three Scandinavian countries [ 66 ].

A total of seven papers from another PBRN, the National Institute on Drug Abuse’s Clinical Trials Network (CTN), also provided evidence of accelerated translation, identified mechanisms through which this might work, and discussed the theoretical frameworks within which those operated [ 5 , 14 , 23 , 49 , 63 , 90 , 91 ]. Thus, Ducharme et al. [ 14 ] and Knudsen et al. [ 23 ] explored Rogers’ notion of the “trialability” [ 110 ] of innovations, that is, how far an innovation may be experimented with on just a limited basis, and Abraham et al. [ 5 ] discussed the role of absorptive capacity [ 111 , 112 ], which they summarized as an organization’s ability to assess and use information [ 5 ]. Rieckmann et al. noted that although the mechanisms involved were not fully understood they appeared “to be influenced by core experiences from network participation” (p. 894) [ 91 ], and Fields et al. [ 63 ] used insights from implementation science to explore the influence of a set of organizational characteristics (including network membership) on innovation adoption [ 113 ].

In an analysis of data on 12 993 transplants conducted in 162 US centres, the 32 centres in the Bone Marrow Transplant trials network were found to have significantly better survival rates than others [ 77 ]. Marmor et al. reported that there was not an association between procedure volume and survival. Rather, they suggested, the better outcomes for those treated in centres in this network could be linked to the nature of trials that required “higher levels of national clinical collaboration and standardization of protocols”, and such collaboration was “likely to generate higher levels of innovation and excellence among clinical colleagues” (p. 92) [ 77 ].

In Germany, one team produced three papers on the improved healthcare performance of hospitals that were part of clinical trials organizations [ 13 , 34 , 94 ]. Two papers described the improved outcomes for patients with ovarian cancer if they were treated in a hospital that belonged to one of two German ovarian cancer clinical trials organizations, in effect research networks [ 13 , 34 ]. They noted that the improved outcomes were not related to patient volume, suggesting instead that possible factors may include hospitals’ participation in the study group’s quality assurance programs and team members attending regular and scientific and educational meetings [ 13 ]. In a follow-up study, the data were analysed in more detail using mediation analysis that showed not just that the research participation of a hospital contributed to superior patient survival, but also began to unpick how it happened, including through better use of surgery and chemotherapy [ 94 ].

Downing et al. noted that, following the 2006 establishment of the NIHR in the United Kingdom, the increase in research activity in networks throughout the English NHS also increased the scope for analysing the benefits of research engagement [ 58 ]. The role of NIHR networks in boosting research engagement, which is then linked to improved healthcare, also covers clinicians such as nurses and AHPs who had traditionally had limited research opportunities. Studies are now showing how they can play an important role by engaging in research because, according to Trusson et al. reporting on a research network for nurses and AHPs, people working in such roles “have opportunities to explore possible solutions to issues that they encounter in their clinical role through academic study” (p. 1) [ 101 ]. Such opportunities can also enhance their clinical skills. More broadly, Downing et al. claimed that, in relation to the NIHR’s clinical trials network, “this natural experiment, presented by the rapid expansion of trial activity across a whole national health system, is perhaps the best opportunity to address the subject though outcomes research” (p. 95) [ 58 ]. This development is discussed in the next section.

The “dose effect” of the extent of research engagement

Evidence indicating a link between the extent of research engagement and the degree of improved healthcare has been accumulating for some time. In the United States, the 1996 study by Brown and Griffiss found that the average acute length of stay (LoS) in Department of Veteran Affairs hospitals was inversely related to the size of research programmes [ 53 ]. Majumdar et al. [ 26 ] used a tertile approach to show that in-hospital mortality decreased as the rate of trial participation increased in the area of unstable angina. In the substance abuse field, early CTN studies also contributed: thus Knudsen et al. [ 23 ] noted that the adoption of buprenorphine therapy by practitioners within the trials’ network was much greater in those programmes in the network that participated in the specific buprenorphine trial than those that had not. In a 2006 study of a sexual health trial in Australia, Morton et al. [ 28 ] identified improved post-trial clinical practice by high-recruiting clinicians, but not by low-recruiting ones.

In our combined set of papers the first use of the specific term “dose effect” to describe the effects of differing amounts of research engagement occurred in Downing et al., who tested the hypothesis that for colorectal cancer (CRC) “high, sustained hospital-level participation in interventional clinical trials improves outcomes for all patients with CRC managed in those research-intensive hospitals” (p. 89) [ 58 ]. They found that high participation in such clinical trials was independently associated with better outcomes and that these effects were not restricted to academic centres or large institutions but were seen across all the NHS Trusts that conducted research on and treated patients with colorectal cancer. They extended their analysis to look at the effects of different levels of research participation and found that the highest levels of participation led to the highest levels of improved outcomes. However, in relation to these findings, Downing et al. were careful to say that, in the absence of the possibility of an RCT, caution was needed if attempting “to infer a causal contribution” (p. 89) from participation in research activity to improved healthcare [ 58 ].

Other United Kingdom database studies support the findings of Downing et al. For example, Ozdemir et al. [ 85 ] compared mortality with research funding per hospital bed in hospitals with high, medium and low levels of research funding and showed that not only was mortality lower in high-funded research hospitals than in other hospitals, but also, on average, hospitals in the middle category had a lower mortality rate than ones with the least research funding. In two studies using NIHR research study activity data from different years, Jonker and Fisher [ 68 , 69 ] showed an inverse correlation between the number of clinical trials/patient participation levels in United Kingdom hospitals and the mortality rate. Lin et al. [ 73 ] used retrospective data to examine the survival rate of the 465 patients (recruited by 60 hospitals) who had participated in an RCT in the NIHR Clinical Research Network (CRN). While they identified a significant association between low trial recruitment and lower survival rates, looking at the volume of patients treated in the disease area by the respective hospitals they report that “no significance was found between hospital throughput and outcomes” (p. 40) [ 73 ].

Further support for the “dose effect” concept comes from the United States and elsewhere. According to Abraham et al., in the substance abuse field “treatment programs participating in a greater number of CTN protocols had significantly higher levels of treatment quality, an association that held after controlling for key organizational characteristics” (p. 232) [ 49 ]. Similarly, Gilbert et al. [ 66 ] reported that members of a dental PBRN who fully participated in the network were more likely to move evidence-based care into everyday practice than members who only partially participated. Seaburg et al. [ 96 ] showed an association between the quantity of resident physicians’ publications and their clinical performance scores during training, and García-Romero et al. claimed that increases in the scientific output of Spanish hospitals made a significant contribution to a reduction of hospital LoS [ 65 ].

In Canada, Tsang et al. [ 103 ] conducted a pre-planned observational study nested within a clinical trial to test how well traditionally non-research active community hospitals could participate in an RCT alongside the traditional RCT sites in academic hospitals. However, while that aspect of the study did show that, in terms of adherence to trial metrics, the community hospitals could successfully participate in studies, outcomes for patients in the trial were significantly better in the traditional research hospitals, although the full reasons for this will need further exploration [ 103 ].

  • Health equity

Various aspects of health equity are considered in the included papers, and some of these report attempts to improve health equity. Some population groups are particularly vulnerable. In the United States, for example, Wolfson et al. listed the following groups: “underrepresented minorities, those with low socio-economic status (SES), those with public or no insurance, and those with a significant distance to care” (p. 3886) [ 106 ]. On the basis of its long-held assumption that patient access to research active healthcare providers is beneficial, the NCI has attempted to reduce geographic inequalities in access. In a 1995 paper, Warneke et al. noted that the CCOP was established by the NCI in 1983 with the deliberate intention of spreading the benefits of the clinical research conducted in NCI centres: “The program was designed with the assumption that by participating as equals in the research process, community physicians would be more likely to accept and implement the results in their practices with non-protocol patients” (p. 336) [ 37 ].

Similar moves to encourage wider participation in clinical trials have recently been made in Canada in the nested study described above [ 103 ]. A recent analysis showing higher levels of research activity within the English healthcare system were associated with lower mortality, noted that although the NIHR CRN was established to promote research participation across England, there was still some way to go to ensure greater geographical equity [ 69 ].

Other initiatives, such as the United States minority-based CCOPs described in the Glossary, addressed racial inequalities in relation to access to research engagement and timely evidence-based healthcare. These sometimes overlap with geographic inequalities. Some of the papers on the NCI-designated cancer centres observed with concern that the proportion of certain racial/ethnic groups, including African Americans, who received treatment at these centres compared with non-NCI centres, was lower than for other racial groups [ 64 , 80 , 106 ]. Having noted that African Americans with colon cancer experienced worse outcomes than Caucasian Americans, and suggested that this was partly due to differential treatment, a study by Penn et al. found evidence that African Americans receiving treatment from CCOP providers had benefitted from a seemingly deliberate attempt to boost early access to a recently recommended innovative treatment [ 87 ]. In Australia, Young et al. [ 109 ] reported that the health services, and health research system, of the Aboriginal community work together to try to ensure health research is embedded into activities that improve health, and described a specific example in relation to ear, nose and throat surgery and speech-language pathology services.

Lessons from the overall collection of studies: positive and negative

A wide variety of papers contribute to the combined review’s overall finding that the included studies are overwhelmingly positive. As the section on the “dose effect” illustrates, throughout the time covered by the combined review, individual papers have contributed to a wider understanding that goes beyond specific issues about research networks. Many papers contribute to the analysis of both the strength of the association between research engagement and improved healthcare, and the mechanisms involved. For example, a 2019 US positive study by Fanaroff et al. [ 60 ] identified improved care and outcomes for patients with acute myocardial infarction who were treated at research active hospitals, even after accounting for potential confounders. The authors encapsulated some of the key thinking on research engagement with their conclusion that participation in clinical trials by hospitals “may be emblematic of a culture that embraces novel therapeutics, engages both clinicians and patients, and incentivizes continuous improvement in care” (p. 191) [ 60 ].

While overall the 95 studies included in the combined review are positive, about 10% are categorized as negative. These nine negative papers also provide important insights [ 7 , 11 , 15 , 20 , 25 , 67 , 79 , 81 , 99 ]. For example, existing widespread use of one proven intervention prior to a company-sponsored clinical trial exploring physicians’ adherence to international treatment recommendations meant that the trial had no significant impact on that adherence, although it did increase use of the trial sponsor’s drug [ 7 ]; physicians adopted another trial intervention before it was proven one way or another [ 11 ]; more positively, a unique policy and regulatory environment governing the adoption of another intervention ensured that all hospitals benefitted, not just those in the trial [ 79 ]. Two teams with negative results later conducted further, more comprehensive studies with positive conclusions [ 25 , 26 , 67 , 68 , 69 ]. Six of the seven papers examining whether NCI-designated cancer centres provided patients with better healthcare processes and outcomes are positive [ 52 , 64 , 80 , 84 , 86 , 106 ]. However, one paper suggested that outcomes were worse in these accredited hospitals despite the better healthcare and, in seeking to explain this, drew attention to the factors considered in the accreditation processes used by different organizations and how far they accurately captured the most relevant data [ 81 ].

Our original review set out to find whether there was empirical evidence that supported the often-held assumption that engagement by clinicians and healthcare organizations in research improves healthcare performance at various levels. It concluded that there was some positive evidence but that systematic analysis of the data related to this engagement was in its infancy [ 2 ]. The 62 papers in the updated review, 58 of which are positive, provide further empirical evidence to support the positive conclusions of the original review.

When the papers from both reviews are considered together, they provide a more complete dataset than previously available [ 1 , 2 , 3 , 4 ], and an updated picture of this literature in which the trends identified in our initial analyses [ 3 ] become more apparent. With more than a third of the papers in the combined review (32/95) focussing on aspects of cancer, this is the field overall in which there is the most comprehensive analysis of the link between research engagement and improved healthcare. While the individual cancer papers differ in the strength of the association identified, and most of the papers focus one or other of the main cancer sites, many of the cancer papers analyse the role of research networks – one of the main mechanisms through which it is claimed research engagement improves healthcare.

The combined review reflects policy shifts and organizational changes that occurred first in the United States and later in the United Kingdom and elsewhere, and were designed to address the time lag between the production of research and its use in practice. These include the development of research networks and their associated databases over several decades (accompanied by an improved understanding of their strengths and limitations [ 54 , 64 , 77 , 106 , 108 ]) and efforts to strengthen links between academic centres and community services [ 61 , 87 ]. More recent developments, especially in the United Kingdom, encouraged further deliberate attempts to identify and explore the impacts of research engagement. Research teams were, for example, better able to study the real-world impacts of system-level mechanisms such as research networks as they became more formalized and embedded in national health and science structures [ 58 , 67 , 68 , 69 , 85 , 93 , 101 ].

Across the board, within and beyond networks, there is also further evidence about the mechanisms by which research engagement might improve healthcare, including the ones identified in our original review. The role of strong evidence-based protocols developed for RCTs, but contributing to improved healthcare more widely in research active healthcare sites, was highlighted in various studies [ 77 , 98 , 105 ]. Papers also identified the importance of providing evidence-based/guideline consistent care, which could also be linked to a culture of discovery, excellence and collaboration [ 40 , 60 , 62 , 64 , 77 , 84 , 86 , 87 , 106 ]. There were also more nuanced mechanisms at the speciality and clinician levels, such as the use of multi-disciplinary coordination of care in radiation therapy treatment [ 107 ] and practitioner skill development in substance abuse work [ 90 ]. Similar practitioner skill development was also reported among nurses and AHPs, including in the wider literature [ 31 , 38 , 39 , 62 , 70 , 101 ].

In the combined review it also became easier to see connections across this diverse literature. It was possible to identify research teams that had worked together on multiple studies and to explore the extent of cross referencing. In the United States, for example, the CTN of the drug abuse institute had been created to emulate the CCOP, and a centre was established to assess the CTN’s impact [ 114 ]. Analysis of this research network highlighted its role both in conducting research that was relevant to the “real-world” needs of clinical settings, and in enhancing evidence-adoption by healthcare organizations and staff [ 114 ]. Many of the papers from this substance abuse CTN [ 23 , 49 , 90 ] referenced each other and also cross-referenced key cancer papers [ 8 , 24 , 54 ], and there was common use of the same early sources [ 110 , 112 , 115 , 116 ]. These interactions prompted ongoing methodological development, strengthened understanding of theoretical concepts, and supported shared learning across the specialities. Additionally, themes that had been recognized in the original review, including concepts such as absorptive capacity [ 5 , 111 ], were further explored and tested in new contexts, even if the same literature was not always drawn upon [ 40 , 65 ].

In the combined review, the nature and strength of the association found between research engagement and improved health varies enormously among the 86 positive papers, even among those that describe the role of research networks. One approach that begins to identify where evidence might be strongest was noted in the original review as being the important concept of the “dose effect”, even if it was not specifically labelled as such [ 26 ]. However, the combined review can now more fully consider the concept because evidence about this greatly increased as the scope of the papers included has increased. There are many more studies where all the clinicians or organizations compared are engaged in research but to varying extents and/or with different levels of resources, for example within a trial [ 28 , 50 , 59 , 73 , 93 , 103 , 107 ] or within a network [ 23 , 33 , 49 , 51 , 66 , 68 , 69 , 85 , 95 ]. The inclusion of papers regarding differences within trials, and the emergence of the importance of the “dose effect”, have implications for both (a) how the issue of research engagement is analysed and (b) how far efforts to enhance research engagement should be concentrated or spread widely across a system.

In relation to the first of these issues, when considering how research engagement is analysed, the key question morphs somewhat: it is no longer simply whether research engagement improves healthcare performance compared with no research engagement, rather, it is whether a larger amount of research engagement improves healthcare performance by more than a smaller level of engagement (and, if so, by how much). Answers to these questions could then feed back to strengthen the evidence for a positive association between research engagement and improved healthcare performance.

In relation to the second question, about the concentration or wide distribution of research funding, analyses might have to consider the context and trade-offs in terms of benefits for improved health and health equity. The widespread distribution of research funding across the health system could maximize the number of patients who might benefit, but a more concentrated approach, with a higher dose of research engagement in a smaller number of hospitals, could maximize the benefit for patients in such centres.

Research infrastructures in countries such as the United States and United Kingdom have been developed to enhance the relationship between health and health research systems, and the evidence from our combined review suggests that these changes have been positive. In both systems, but particularly in the United Kingdom, there have been deliberate attempts to fund major centres of research in leading healthcare facilities, as well as to spread research funding more widely to healthcare organizations across the country, but this impetus needs to be maintained if the full benefits of research engagement are to be realized.

Such an argument is reinforced by the conclusions of a major recent analysis of progress in the United Kingdom in engaging healthcare staff in research and building research capacity. The findings from the study suggest that many healthcare staff in the United Kingdom are interested in being involved in research, there are supportive national policies and strategies in place and there has been some important progress. However, achieving widespread involvement “will only be possible by focusing more on how healthcare organizations embed and support research activity through organizational policies which are supported by the wider research support and funding infrastructure. This is an essential part of a system-based approach to developing and supporting research engagement” (p. 356) [ 117 ]. The progress possible, and the potential benefits of trying to build a health research system embedded into a healthcare system, but also the full range of substantial challenges, have also recently been explored in a hospital and regional healthcare system in northern Queensland, Australia [ 118 , 119 ]. Studies such as these indicate that this combined review could provide timely evidence to further the challenging task of improving healthcare by boosting engagement in health research.

Strengths and limitations

The combined review contains a considerable number of papers from diverse perspectives, but the literature is drawn predominantly from the United States and the Global North, thus the conclusions may not be appropriate in different contexts, including in the Global South. This, perhaps, partly reflects the inclusion criteria of papers in English only. While the increasing use of bibliometrics as an indicator of research engagement has widened the range of positive studies available, differing claims as to the most appropriate measure of research publications challenge consistent interpretation of the data and indicate there is more work to do. Furthermore, it is important to recognize that the national policy, noted in one paper, of attaching promotion and bonuses for clinicians to publish in journals with an impact factor of at least three [ 97 ] runs contrary to the internationally widely endorsed Declaration on Research Assessment [ 120 ].

The complexity of this literature (with many generic terms such as “research” and “engagement”), and the tangential approach of some papers to the broad question of whether research engagement improves performance, posed considerable challenges. It helped enormously that this time around, we were able to build on our experience in the original review. We adopted a somewhat more extensive approach to the formal search in the updated review, and we identified some papers that we had missed in the original review. We were aided by the generally greater clarity in later papers. We are now able, therefore, to present a more nuanced understanding of this field, building on our experience in the original review. In particular, we have found considerably more evidence on two topics identified as important in our original review, and on their implications for health equity: the role of research networks and consideration of how far there is a dose effect with regard to the degrees of research engagement. On both topics the combined review has strong papers showing important healthcare improvements even after considering potential confounders such as patient volume [ 8 , 13 , 26 , 40 , 58 , 73 , 77 , 84 , 85 , 86 ]. However, the failure of some papers to address such confounders [ 59 , 107 ] means some weaknesses in the overall analysis remain, and we are still not able to undertake any meta-analysis as the included literature remains very diverse.

We have now included a significant range of largely positive papers in the combined review. However, lack of resources meant we were not able to replicate our original review’s [ 2 , 3 ] structured analysis of the wider range of papers identified as making many relevant and illuminating points related to the topic, but not meeting the review’s inclusion criteria. For example, while the combined review does include some consideration of health equity issues, there were papers taken to full paper review that were not in the end included but which provide considerably more evidence [ 121 , 122 ].

Future possible work

The system-based approaches for expanding the amount of research in healthcare systems that are mentioned above continue to provide important opportunities for further work on exploring the relationship between research engagement and improved healthcare, including the implications for health equity. Likewise, improvements in the identification and collection of relevant data and developments in statistics have prompted increasingly sophisticated analyses, sometimes using approaches developed in other fields, and could continue to do so [ 65 , 90 , 94 ]. There has also been increasingly sophisticated use of bibliometrics, and there are likely to be continuing opportunities to apply such approaches to more countries. However, the warning from Downing et al. that caution is needed if attempting “to infer a causal contribution” from research participation to improved health outcomes [ 58 ], as well as frequent mention of similar disclaimers in other papers [ 8 , 40 , 54 , 59 , 69 , 74 ], is a reminder that more work is needed.

While some of our papers have claimed that the costs of research engagement are broadly covered by the associated reduced LoS [ 53 , 65 ], further research might be useful around the costs associated with research engagement and how these relate to reported benefits. Such studies could add to the existing large-scale studies showing the considerable monetary value of the health and economic gains resulting from health research [ 123 ].

The insights revealed by the negative papers, particularly in relation to the contexts in which research and research networks operate [ 99 ], could usefully be further explored. Merkow et al. [ 81 ], the one negative paper out of seven papers included on the NCI-designated centres, raises issues about the accuracy, or perhaps appropriateness, of the measurement used by various organizations to accredit cancer centres. These issues have also been explored by various teams [ 122 , 124 , 125 ] but could perhaps be worth further examination because the findings from Merkow et al. are so starkly different from those of other papers included in our review.

Finally, there are increasing opportunities, as well as a growing need, to address the limitations identified above (and also noted in the review by Chalmers et al. [ 39 ]) and go beyond the formal inclusion criteria of this review. A major area that could usefully be incorporated into an overall analysis of the field relates to the impact of the growing interest in research engagement strategies [ 126 ]. This includes the efforts to enhance research roles for healthcare professionals other than medical professionals [ 38 ], and the increasing number of organizational arrangements within health and health research systems for partnerships that seek to boost the production and use of relevant evidence [ 127 , 128 ].

Previous reviews [ 1 , 2 , 3 , 4 ] have investigated the association between research engagement and improvements in healthcare performance. This study updates and extends the most comprehensive of these reviews [ 2 , 3 ], and combines its findings with those from that original review to produce a more substantial pool of studies, which are largely positive in terms of the impact of research engagement on processes of care and patient outcomes. Of potential mechanisms, the combined review highlights the important role played by research networks and further identifies the various ways the research engagement facilitated by them operates to improve healthcare. The review also draws together a set of papers which consider how far there is a research engagement “dose effect”. Given the difficulty of conducting randomized controlled trials of large-scale research engagement initiatives, studies of the dose effect offer another approach to understanding the potential contribution and complexities of research engagement, including the implications for health equity. This review provides further evidence of the important contribution played by systems-level research investments such as research networks on processes of care and patient outcomes.

Availability of data and materials

No datasets were generated or analysed during the current study.

Abbreviations

Allied health professionals

Clinical research network

Clinical trials network

Community Clinical Oncology Program

Length of stay

Mixed-methods appraisal tool

National Cancer Institute

National Health Service

National Institute for Health (and Care) Research

Practice-based research network

Research and development

Randomized controlled trials

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Acknowledgements

The authors would like to thank Teresa Jones for her expert advice on the search strategy. The review was completed as partial fulfilment of Belinda Goodenough’s Masters dissertation at King’s College London. In the original full report for our first review [ 3 ], we gratefully acknowledged the valuable help we had received from our expert advisory group. The members included two patient representatives who were consulted at various stages throughout the project, especially around the necessity of having our systematic review focus on the complexities of benefits from research engagement by healthcare organizations and staff, while separate reviews and analyses focussed on the benefits of PPI in health research.

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Annette Boaz

The Sax Institute, Sydney, NSW, Australia

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Brunel University London, Uxbridge, United Kingdom

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All authors were involved in planning the study. B.G. conducted the searches, with all authors involved in screening and analysis. B.G. produced an initial draft of the paper. The final version of the paper was produced collaboratively by all the authors.

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Correspondence to Annette Boaz .

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Boaz, A., Goodenough, B., Hanney, S. et al. If health organisations and staff engage in research, does healthcare improve? Strengthening the evidence base through systematic reviews. Health Res Policy Sys 22 , 113 (2024). https://doi.org/10.1186/s12961-024-01187-7

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DOI : https://doi.org/10.1186/s12961-024-01187-7

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WHO declares mpox global health emergency

essay the importance of health

The World Health Organization (WHO) has declared the mpox outbreak in parts of Africa a public health emergency of international concern.

The highly contagious disease - formerly known as monkeypox - has killed at least 450 people during an initial outbreak in the Democratic Republic of Congo.

It has now spread across parts of central and east Africa, and scientists are concerned about how fast a new variant of the disease is spreading and its high fatality rate.

WHO chief Tedros Adhanom Ghebreyesus said the potential for further spread within Africa and beyond "is very worrying".

"A co-ordinated international response is essential to stop this outbreak and save lives," he said.

Mpox is transmitted through close contact, such as sex, skin-to-skin contact and talking or breathing close to another person.

It causes flu-like symptoms, skin lesions and can be fatal, with four in 100 cases leading to death.

Outbreaks can be controlled by preventing infections with vaccines, though these are usually only available for people at risk or those who have been in close contact with an infected person.

  • Explained: What is mpox and how is it spread?
  • Podcast: What does the new mpox strain mean for you?

There are two main types of mpox - Clade 1 and Clade 2.

A previous mpox public health emergency, declared in 2022, was caused by the relatively mild Clade 2. However, this time it is the far more deadly Clade 1 - which has killed up to 10% of those getting sick in previous outbreaks - that is surging.

There was a change in the virus around September last year. Mutations led to an offshoot - called Clade 1b - that has since spread rapidly. This new variant has been labelled “the most dangerous yet” by one scientist.

Since the start of the year, there have been more than 13,700 cases of mpox in the DR Congo, with at least 450 deaths.

It has since been detected in other African countries - including Burundi, the Central African Republic, Kenya and Rwanda.

It is hoped the declaration of mpox as a public health emergency will lead to research, funding, and the introduction of other international public health measures being accelerated.

Dr Josie Golding, from the Wellcome Trust, said it was a "strong signal", while Emory University's Dr Boghuma Titanji said the move "underscores the gravity of the crisis".

Prof Trudie Lang, the director of the Global Health Network at the University of Oxford, said it was "important and timely", but added that the emergence of a new strain meant there were "many unknowns that need to be addressed".

In July 2022 the milder Clade 2 strain of mpox spread to nearly 100 countries , including some in Europe and Asia.

It spread rapidly, and there were more than 87,000 cases and 140 deaths reported during that outbreak, according to a WHO count.

Although anyone can catch monkeypox, the outbreak was largely concentrated among men who had sex with men.

That outbreak was brought under control by vaccinating vulnerable groups.

On Tuesday, scientists from the Africa Centres for Disease Control and Prevention declared a public health emergency.

The head of the organisation, Jean Kaseya, warned that this current outbreak could spiral out of control if immediate steps were not taken to contain it.

"We must be proactive and aggressive in our efforts to contain and eliminate this threat," he said.

Additional reporting by Alex Smith

  • DOI: 10.47535/1991auoes31(2)014
  • Corpus ID: 257268205

UNETHICAL BEHAVIOR: A MULTIDISCIPLINARY REVIEW OF THE HIGHLY CITED PAPERS

  • Alina Beattrice Vladu , D. Matica
  • Published in The Annals of the University… 1 December 2022
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Plant-derived terpenoids: a plethora of bioactive compounds with several health functions and industrial applications—a comprehensive overview.

essay the importance of health

1. Introduction

Biosynthetic pathways, 2. terpenoids as semiochemicals, 2.1. insect–plant activity, 2.1.1. terpenoids with toxic or repellent properties, 2.1.2. terpenoids as attractants.

Plant SpeciesTerpene ID and ClassTargetMechanism and EffectRef.
(Euphorbiaceae)Oxygenated terpenoid resinsFemale euglossine (Aphidae), female anthidiine (Megachilidae) beesReward to pollinators[ , ]
(Ficus hispida)Linalool; limonene and β-pinene (monoterpenes)Wasp (Ceratosolen solmsi marchali)Signaling pollinators[ ]

(Hesperis matronalis)
Linalool; β-ocimene (monoterpenes)Mainly syrphid flies (Syrphidade)Attractant to pollinators[ ]

(Brassica species)
1,8-cineole (monoterpenes)Parasitic wasps (Cotesia glomerata)Attractant to parasitoids that lay eggs in herbivores larvae[ ]
(Z)-3-hexenyl acetate; (Z)-3-hexenol; (3E)-4,8-dimethyl-1,3,7-nonatriene; and linaloolPest predator (Chrysopa phyllochroma)Attractant to predators and promotes oviposition[ ]

(Solanum lycopersicum) and
(Nicotiana tabacum)
Β-ocimene (monoterpenes)Parasitoid (Aphidius ervi)
Pest (Macrosiphum euphorbiae)
Attractant to parasitoids and defense against pest[ ]

(Lavandula angustifolia)
Β-trans-ocimene; (+)-R-limonene (monoterpenes)Aphids (Aphidoidea family)Pest deterrent[ ]
(Cinnamomum genus) and

(Syzygium aromaticum)
Eugenol; caryophyllene oxide; α-pinene; α-humulene and α-phellandrene (monoterpenes)Wheat weevil (Sitophilus granaries)Toxic and repellent effects on adult specimens[ ]

(Eucalyptus grandis)
A-pinene; γ-terpinene (monoterpenes)Eucalyptus gall wasp (Leptocybe invasa)Attractant to pest[ ]
Geraniol (terpenoid)Sweet potato whitefly
(Bemisia tabaci)
Encapsulated geraniol shows attraction to that specimen[ ]

2.2. Antifungal Activity

3. terpenoids ir1n human health, 3.1. terpenoids on cancer prevention, 3.2. terpenoids in the prevention of cardiovascular diseases, 3.3. neuroprotective effects of terpenoids.

TerpenoidAssayReported ActivitiesRef.
ArtesunateC57BL/6 mice (newborn) and primary neural stem/progenitor cells (NSPCs)Ameliorated the insufficient endogenous neural stem/progenitor cell (NSPC) proliferation caused by ischemia. By stimulating the PI3K/Akt signaling pathway, ART could increase the phosphorylation level of FOXO-3a, downregulate p27kip1, and inhibit the transcription of FOXO-3a.[ ]
Asiatic acidNeuronally differentiated PC12 cellsProtection against Aβ25-35-induced apoptosis and tau hyperphosphorylation by regulating PI3K/Akt/GSK-3β signaling.[ ]
AsiaticosideStreptozotocin (STZ)-induced diabetic cognitive deficit rat modelAmeliorated cerebral oxidative stress, inflammation, and apoptosis.[ ]
CatalpolStreptozotocin-induced hyperglycemic miceAntioxidant and neuroprotective effects on mouse models of depression, improving their depressive behavior by upregulating the PI3K/Akt/Nrf2/HO-1 signaling pathway.[ ]
Stroke model and the primary neurons from the rat stroke modelCatalpol activated the PI3K/Akt/mTOR pathway, decreasing the expression of miR-124 and increasing the expression of downstream protein S6, thus enhancing in vivo axon growth and neuronal survival in stroke models.[ ]
CelastrolAcute spinal cord injury ratsInhibited microglial pyroptosis and attenuated inflammatory reactions.[ ]
GeniposideEpileptic rats modelActivated Akt, followed by increased PI3K and GSK-3β expression, thus improving pathological symptoms.[ ]
Hippocampal neuronsInhibited apoptosis, resulting in antidepressant properties in the brain.[ ]
Chronic constriction injury model of neuropathic painInhibited the EGFR/PI3K/Akt signaling pathway, thereby alleviating pain symptoms in the sciatic nerve.[ ]
Bilobalide and ginkgolidesRat model of middle cerebral artery occlusionSupported neuronal cell survival in patients suffering from ischemic stroke.[ ]
PC12 neuronal cellsBilobalide derivatives (diAc-iso and diBrBn-iso) performed better than the original compound (proliferating cell activity, neuroprotective effects against Aβ (1–40) peptides, and neurite outgrowth effects).[ ]
Ginkgolide BRats cerebral I/R damage modelActivation of Nrf2 and CREB through PI3K/Akt signaling.[ ]
Rat model of middle cerebral artery occlusion (MCAO) and OGD/R cell modelAntioxidant effects against cerebral ischemia injury by activating the Akt/Nrf2 pathway.[ ]
Ginkgolide KPrimary cortical astrocytes from newborn mice exposed to oxygen–glucose deprivationSuperior therapeutic potential to ginkgolide B; easier to upregulate PI3K and p-Akt expression, affecting downstream pathways, thereby contributing to anti-inflammatory and antioxidant effects.[ ]
Echinocystic acidCollagenase-induced intracerebral haemorrhage miceNeuroprotective effect via the PI3K/Akt pathway.[ ]
Methyl lucidoneHT-22 cell lineNeuroprotective effects on glutamate-induced oxidative stress in HT-22 cells via Nrf-2/HO-1 signaling.[ ]
LimoneneMaternal separation miceAntidepressant-like effects due to the reduction of nitrite levels in the hippocampus.[ ]
LycopenePrimary mouse neuronsProtected against T-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.[ ]
Platycodin DPrimary cortical neuronsProtected cortical neurons against oxygen–glucose deprivation/reperfusion in neonatal hypoxic–ischemic encephalopathy.[ ]
Polygalasaponin F-Glutamate-induced cytotoxicity cell model/protects hippocampal neurons against glutamate-induced cytotoxicity.[ ]
Rat adrenal pheochromocytoma cells (PC12) and primary rat cortical neuronsInhibited neuronal apoptosis induced by oxygen–glucose deprivation and reoxygenation through the PI3K/Akt pathway.[ ]
GinsenosidesOxygen–glucose deprived (OGD) SH-SY5Y cellsNeuroprotective effect of panax notoginseng saponins by activating the EGFR/PI3K/Akt pathway.[ ]
Mouse modelProtective effects of notoginsenoside R1 via regulation of the PI3K-Akt-mTOR/JNK pathway in neonatal cerebral hypoxic–ischemic brain injury.[ ]
α-PineneFocal cerebral I/R in ratsNeuroprotective effect during ischemic stroke by attenuating neuroinflammation/ELISA.[ ]

4. Industrial Applications of Terpenoids

4.1. pharmaceutical and medical industry, 4.2. cosmetics industry, 4.3. food industry, 5. green emerging extraction techniques, 5.1. pressurized liquid extraction (ple).

MatrixExtraction ConditionsMain ConclusionsRef.
Orange juice by-productsAmount of 4 g orange powder residue + 8 g sea sand (1:2 w/w) placed into the extraction cell; 25 mL ethyl acetate; 96 °C, 30 min, 10 MPa, on static mode; 1 min of N purging; extracts stored in −20 °C in dark before drying; GC-q-TOF-MS analysis.Terpenoids revealed promising neuroprotective action.
Antioxidant activity: ABTSIC50 = 13.5 μg/mL; ROSIC50 = 4.4 μg/mL.
Anticholinesterase activity: AChEIC50 = 137.1 vg /L; BChEIC50 = 147.0 μg/mL.
Anti-inflammatory properties: against IL-6 and LOXIC50 = 76.1 μg/mL, with low cytotoxicity and protection against L-glutamic acid in cell models.
[ ]
Microalgae Spirulina, Chlorella, and Phaeodactylum tricornutumMicroalgae and diatomaceous earth completely mixed (0.5 g: 1.5 g) in a mortar and placed into PLE extraction tank ASE-200 Accelerated Solvent Extractor (preheating for 1 min, heating time of 5 min, flush volume 60%, N for 60 s, 103.4 bars, 40 °C, 15 min); 100% DMSO; HPLC analysis.The authors found that 100% DMSO allowed for the extraction of antioxidants and pigments from Chlorella (polyphenols 10.465 mg/g, chlorophyll a 6.206 mg/g, chlorophyll b 3.003 mg/g, carotenoids 0.971 mg/g) and was thus the chosen concentration for the recovery studies on Spirulina, Chlorella, and Phaeodactylum tricornutum. Fucoxanthin, β-carotene, zeaxanthin, and lutein were the main carotenoids found in P. tricornutum, Spirulina, and Chlorella, respectively.[ ]
Cinnamon, thyme, cumin, fennel, clove, nutmeg, and orangeAmount of 20 mg of spice or 2 g of orange peels placed in a 20 mL headspace vial; 125 °C, 30 min, 250 rpm; Combi-pal + automatic HS injector; GC-MS analysis (1 mL); HS syringe heated at 130 °C.Static HS extraction allowed for the recovery of extracts with higher concentrations in comparison with hydrodistillation and PLE. For example, eugenol LOD:
Static HS: 0.0022 µg/g;
PLE: 0.03 µg/g.
[ ]
CannabisA total of 5 mg powder samples placed in a 20 mL amber rounded bottom HS vial; CTC autosampler used with an HS static tool in splitless mode; 40 min, 140 °C, 250 rpm; GC-MS/MS analysis (600 μL).Ninety-three terpenoids were identified. Sample preparation methods significantly impacted the chemical fingerprint of the samples when compared to non-treated Cannabis. Static HS extraction allowed for the quantification of natural terpenoid contents of chemovars.[ ]
Citrus leavesA total of 1 g powder sample placed in a 20 mL HS vial + 30 μL internal standard (0.1% n-hexanol); sealed vials mixed thoroughly before being placed on a static 7697A HS auto-sampler, awaiting injection; 15 min incubation at 100 °C; GC-MS analysis.A total of 83 volatile metabolites were identified, including monoterpene hydrocarbons (68.23–95.08%, 21 compounds), alcohols (0.69–26.0%, 8 compounds), sesquiterpene hydrocarbons (0.47–5.04%, 26 compounds), aldehydes (0.12–11.26%, 10 compounds), monoterpenoids (0–0.36%, 7 compounds), esters (0–0.18%, 5 compounds), ketones (0–0.02%, 2 compounds), and miscellaneous compounds (0–1.11%, 4 compounds).[ ]
Hop (Humulus lupulus L.)MAHD was carried out using ETHOS X and ETHOS XL extractors; GC-MS analysis.The highest extraction yield was obtained for fresh hops (20.5 mL /kg ). When 3 kg of the sample were used, this value achieved a value of 17.3 mL /kg . In a pilot reactor (30 kg capacity), high yield increases were seen for pelletized and dried samples in quadruple and double the lab-scale yields, respectively.[ ]
Sage herbal dustAmount of 40 g dry plant material + 400 mL distilled water; MAHD performed in the oven (90, 180, 360, 600, and 800 W) for 2 h; water–oil mixture evaporated through glass pipe connector to be condensed in Unger apparatus; essential oils collected and stored at 4 °C until analysis; GC-MS analysis.A total of 55 terpenoids were identified.
The main compounds in the essential oils are obtained via the following methods:
Hydrodistillation—viridiflorol (21%), camphor (16.54–19.05%), and α-thujone (11%);
MAHD at 90W—camphor (24.88%), α-thujone (22.21%), and eucalyptol (18.37%);
MAHD at 360W—viridiflorol (33.27%) and verticiol (13.71%) (in other MAHD samples, viridiflorol (17.17–23.7%) and camphor (14.46–18.82%)).
[ ]
Withered flowers of Magnolia soulangeana Soul.-Bod.MAHD with uniform heating (623 W, 54 min, 60 r/min); 50 g soaked raw materials + distilled water in a 500 mL distillation flask (6.4 mL/g liquid–solid ratio); withered flowers soaked for 8 h before essential oil preparation; anhydrous sodium sulfate added to remove the moisture; sample transferred to a low-temperature environment (4 °C ± 2 °C) for storage; GC-MS analysis.The introduction of the rotation unit and soaking pretreatment unit increased the yield of essential oil by 16.67% and 20%, respectively. This method showed a lower energy consumption and environmental pressure than conventional approaches for essential oil preparation. The samples obtained were rich in terpenes (49.32%), such as eucalyptol, δ-cadinene, α-muurolene, and germacrene D. δ-cadinene was the main compound to exert hypolipidemic activity.[ ]
Lavenders (Lavandula x intermedia var. Super A)Dried lavenders grinded at 6000 rpm for 10 s and subjected to soaking (1:10, w/v) for 1 h before extraction process. Essential oils of dried lavender extracted via MAHD (ETHOS X) at 750 W for 2 h; GC-MS analysis.Lavender essential oil yield was around 5.5%.
Based on the GC-MS data, major constituents of linalool L (29.0%), 1,8-cineole (13.9%), camphor (12.3%), and linalyl acetate (11.9%) were the main compounds identified.
[ ]
PeppermintAmount of 40 g dry plant material + 400 mL distilled water; MAHD performed in the oven (180, 360, 600, and 800 W) for 2 h; water–oil mixture evaporated through glass pipe connector to be condensed in Unger apparatus; essential oils collected and stored at −18 °C until analysis; GC-MS analysis.Monoterpenes were the main class of compounds in all samples with menthol (33.07–37.43%), menthone (9.49–25.21%), isomenthol (4.27–10.21%), isomenthone (4.51–6.06%), and eucalyptol (1.16–4.89%). Sesquiterpenes were also predominant with trans-caryophyllene (4.58–10.56%) and germacrene D (2.65–7.65%).[ ]
Flesh and peels of 15 matrices of vegetablesAmount of 5 g freeze-dried samples + 95 g inert glass beads; 15 g/min CO ; 30 min, 59 °C, 350 bar, 15.5% (v/v) ethanol as co-solvent; extracts collected and dissolved in ethanol and stored at −18 °C in dark glass containers until analysis; HPLC analysis.TCR values higher than 90% w/w for most samples. β-carotene was the most successfully extracted compound (TCRs 88–100% w/w). More polar carotenoids, such as lutein and lycopene, exhibited lower TCRs.[ ]
Mango peelAmount of 5 g mango peel + 6.7 g/min CO ; 180 min, 60 °C, 25 MPa, 15.5% (w/w) ethanol as co-solvent; after extraction, remanent ethanol evaporated under vacuum (35 °C, 100 mBar); dried extracts stored at −20 °C until analysis; RP-UHPLC-DAD analysis.The extracts provided better protection to sunflower oil against lipid oxidation than all-trans-β-carotene when evaluated between 200–1000 ppm, which contained 6–28 ppm of all-trans-β-carotene.[ ]
Annatto seedsTwo-step sequential SFE extraction:1st step: 60 °C, 10 MPa, 290 kg/m CO to recover the geranylgeraniol-rich fraction; 2nd step: 40 °C, 20 MPa, 840 kg/m CO to recover the tocotrienols-rich fraction. Amount of 50 g annatto seeds packed in the extraction vessel + empty space filled with glass beads; 9.5 g/min CO .Different operational extraction conditions (temperature and pressure) resulted in extracts with different chemical compositions. The extract obtained at low CO density (290 kg/m ) produced a fraction enriched in geranylgeraniol with a low tocotrienols content. A two-step sequential SFE extraction process was employed to obtain a geranylgeraniol-rich fraction followed by a tocotrienols-rich fraction.[ ]
Carrot peels and fleshAmont of 5 g dried peels + 95 g inert glass beads; 80 min, 59 °C, 349 bar; 15 g/min CO ; ethanol as co-solvent (15.5%); HPLC analysis.β-Carotene represented 60% of the TCC in both flesh and peel, followed by α-carotene (30% of the TCC in both samples). In the peels, these two carotenoids accounted for almost 95% of TCC. Lycopene and lutein were also identified (1.9–30.2 μg/g).
The optimum extraction conditions allowed for a carotenoid recovery of 86.1%.
At 58.5 °C, 306 bar, and 14.3% ethanol, the processes retrieved maximum mass yield (5.31%, d.b.).
[ ]
Leaves of Piper klotzschianumAount of 20 g leaves + the remaining extraction cell space filled with inert glass beads; after reaching 79.85 °C, the pump and extractor were simultaneously pressurized (220 bar); system left at rest to reach equilibrium (30 min); extraction was then performed up to 280 min; GC-MS analysis.At optimum conditions, the highest extraction yield was 1.36%. The addition of organic co-solvents (5% of methanol) significantly improved the extraction yield to 2.18%, representing an increase of 40% compared to extraction using CO alone.[ ]
Caraway seedsSWE: 1 g caraway + 2 g diatomaceous earth + 2 cellulose filter papers; sample cell placed in the oven; pump delivered solvent to the sample; cell heated to the set temperature under high pressure, and the extraction was performed for the designated time; after extraction, solvent purged out of the cell using N gas; extract collection.
LLE: water extract + 20 mL n-hexane. Centrifugation (5 min); obtained extract stirred briefly and centrifuged (5 min); n-hexane transferred to an empty conical tube and stored in the freezer; GC and GC-MS analysis.
In SWE, smaller amounts of terpenes (limonene, carveol, and carvone) were found. The limonene concentration was higher for hydrodistillation (5 mg/g ) than for SWE. The carvone yield was higher when using SWE (28.5 mg/g ) than for solvent extraction (20.2 mg/g ) and hydrodistillation (19.8 mg/g ).[ ]

5.2. Static Headspace (HS) Extraction

5.3. microwave-assisted hydrodistillation (mahd), 5.4. supercritical fluid extraction (sfe), 6. concluding remarks, author contributions, institutional review board statement, informed consent statement, data availability statement, acknowledgments, conflicts of interest.

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Click here to enlarge figure

Terpenoid (Source)Cancer Type Assay/Reported ActivitiesRef.
Andrographolide (Andrographis paniculate)C8161 and A375 human malignant melanoma cells/cell cycle arrest and apoptosis[ ]
Betulinic acidA375 melanoma cells/dose-dependent inhibitory effect in both mitochondrial respiration and glycolysis; induced mitochondrial dysfunction (10 μM)[ ]
BorneolGlioma cells/promote apoptosis through the regulation of HIF-1a expression via theMTORC1/EIF4E pathway;
esophageal squamous cell carcinoma cells/enhances paclitaxel-induced apoptosis via the inactivation of the PI3K/AKT pathway
[ , ]
Bornyl cis-4-hydroxycinnamateMelanoma cell/apoptosis via mitochondrial dysfunction and endoplasmic reticulum stress[ ]
(+)-Bornyl p-coumarateMelanoma cells/induced apoptosis and autophagy[ ]
CarvoneMCF-7 breast ductal carcinoma/Protective effect against tumor (IC 14.22 μM)[ ]
Citral (nanostructured lipid carrier)MBA-231 breast cancer cells/in vitro cytotoxicity and anticancer activity[ ]
Chlorinated guaiane-type sesquiterpene lactones (Centaurea plants)U-937 leukemia HL-60 cells/cytotoxicity[ ]
Curcumin and crocinCervical cancer cells/protective and therapeutic effects against tumor cells[ ]
Cucurbitacin C (Cucumber)Cancer-cell-derived xenograft tumors in athymic nude mice/dose-dependent inhibited proliferation and clonogenic potential: cell cycle arrest at G1 or G2/M stage at low-dose; apoptosis at high-dose treatment[ ]
Cucurbitacin ENCI-N87 gastric cancer cells/enhanced doxorubicin cytotoxicity[ ]
HelenalinEmbryonal rhabdomyosarcoma cells/increase ROS levels, decrease mitochondrial membrane potential, trigger endoplasmic reticulum stress, and deactivate the NF-κB pathway[ ]
Hinokitiol (>90%)A549 lung adenocarcinoma/reduced cell migration and chemoprevention[ ]
Limonene (chitosan nanoparticles containing limonene and limonene-rich essential oils)Melanoma and breast cancers/potential phytotherapy agents for cancer treatment[ ]
MyrceneA549 lung adenocarcinoma/increased apoptosis via caspase induction
(IC 0.5 μg/mL), MTT assay
[ ]
MyrtenalB16F0, B16F10, and SkMel-5 melanoma cells/decreased tumor cells migration and invasion[ ]
Oleanolic and ursolic acid derivativesNCI-60 cancer cells/antiproliferative and cytotoxic effects[ ]
ThymoquinoneB16-F10 melanoma cells model/inhibition of melanogenesis[ ]
TriptolideBreast cancer cells/enhanced sensitization to doxorubicin (DNA damage response inhibition)[ ]
α-PhellandreneMelanoma (B-16/F-10), and murine (S-180) cells/antinociceptive and tumor-reducing effect (CI50 436.0 and 217.9 μg/mL); MTT assay[ ]
α-PineneHepG2 liver cancer/reduced cell growth (IR 39.3%), MTT assay[ ]
α-TerpineolMurine sarcoma 180 cell line/antitumor activity against different tumor cell lines (lung, breast, leukemias, and colorectal); blockage of NF-kB expression[ ]
α-Thujone
(Thuja occidentalis L.)
T98G and U-87 MG glioblastoma cells/induction of cell death, reduced proliferation and invasives; TB exclusion[ ]
β-elemene
(Curcuma wenyujin)
β-elemene-derived antitumor drug/antitumor mechanisms and structural modification
A375 melanoma cells/β-elemene enhances radio sensitization
[ , ]
TerpenoidAssay/Reported ActivitiesRef.
ArtemisininRats/attenuates doxorubicin-induced cardiotoxicity and hepatotoxicity[ ]
Rats/renoprotective effects on IgA nephropathy by suppressing NF-κB signaling and NLRP3 inflammasome activation by exosomes[ ]
Human macrophage U937 cells/anti-inflammatory effect on uric acid-induced NLRP3 inflammasome activation through blocking the interaction between NLRP3 and NEK7[ ]
I/R model rats/suppresses myocardial ischemia–reperfusion injury via NLRP3 inflammasome mechanism[ ]
BakuchiolC57BL6 male mice/protective effect limiting the synthesis of fibrosis, preventing oxidative damage and cell death in diabetic myocardium[ ]
C57BL/6J mice and NRCM cells/antihypertrophy effects by modulating the synthesis of fibrosis and inflammatory responses[ ]
BetulinDiabetic mice and glucose-stimulated H9c2 cells/protective impact on injured myocardium; significant reduction in cardiac inflammation (anticardiac inflammatory factor via the SIRT1/NLRP3/NF-κB pathway)[ ]
I/R model rats/significantly improved the abnormal electrocardiograms; decreased myocardial infarction area and expression of myocardial enzymes and inflammatory cytokines and SITI1; decreased protein expression levels of NLRP3 and NF-κB (anti-inflammatory mechanism is associated with the NLRP3/NF-κB signaling pathway)[ ]
Carnosic acidC57BL/6 mice/antiobesity effect by improving hormone homeostasis and reduced gene expression of liver lipogenesis possibly via the PPAR-γ pathway[ ]
C57BL/6 mice/cardioprotective effect against myocardial remodeling by modulation oxidative stress and apoptosis via the AKT/GSK3β/NOX 4 signaling pathway[ ]
C57BL/mice and H9c2 cells/protects the heart against toxicity via the suppression of oxidative damage, inflammation, apoptosis, and autophagy[ ]
CarnosolH9c2 cells/protective effect against inflammation in the cardiomyoblasts may be via the NF-κB signaling pathway[ ]
MAPC cells/promote vascular health by regulating redox status and downregulating inflammation and apoptosis[ ]
CarvacrolWistar rats/protective effect against myocardial hypertrophy by improving blood pressure and inhibiting apoptosis via regulation of the Bcl-2 family protein[ ]
CelastrolRat primary cardiomyocytes and H9C2 cells/prevents myocardium fibrosis and hypertrophy produced by angiotensin II[ ]
HinokitiolSEVC4-10 and A7r5 cells/protective effect against atherosclerosis by modulating cell adhesion molecules and members of the matrix metalloproteinase (MMP) family[ ]
AC16 cells/protects cardiomyocytes from oxidative damage by regulating apoptosis and autophagy, probably through the GSK3β signaling pathway[ ]
FerruginolC57BL/mice and H9c2 cells/cardioprotective action by preserving the mitochondrial from the production of ROS, limiting damage to heart function, and attenuating the apoptotic process, possibly via the SIRT1 pathway that mediates mitochondrial biogenesis and fatty acid oxidation[ ]
Wistar rats/cardioprotective effect against myocardial infarction via modulation of inflammatory response and upregulation of antioxidant enzymes[ ]
GeniposideSpontaneous hypertensive rat/modulates blood pressure by inhibiting the WNK pathway mediated by the estrogen receptors[ ]
I/R model rats and H9C2 cells/inhibition of autophagy via geniposide protects against myocardial I/R injury[ ]
Neurons and PC-12 cells/inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen–glucose deprivation/reoxygenation[ ]
Mice/protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway[ ]
OridoninRenal proximal tubular epithelial cells and acute lung injury mice model/suppressed NF-κB or MAPK activation and release of TNF-α and IL-6[ , ]
Rats/drastically diminish the extent of myocardial infarction and the blood cardiac enzymes[ ]
Mice/attenuates myocardial I/R injury by downregulating oxidative stress and the NLRP3 inflammasome pathway[ ]
Mouse models of peritonitis, gouty arthritis, and type 2 diabetes/specific covalent inhibitor of NLRP3 inflammasomes, inhibiting the assembly and activation of NLRP3 inflammasomes[ ]
RAW264.7 cells and mouse model/protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways[ ]
PterostilbeneRat heart subjected to ischemia–reperfusion/attenuates inflammation via the TLR4/NF-kB signaling pathway[ ]
SwerosideH9c2 cells/protects against myocardial ischemia–reperfusion injury by inhibiting oxidative stress and pyroptosis partially via modulation of the keap1/Nrf2 axis[ ]
H9c2 cells/ameliorate the cardiotoxicity of aconitine and the incidence of arrhythmias generated by aconitine[ ]
H9c2 cells/protect against myocardial ischemia–reperfusion injury by inhibiting oxidative stress and pyroptosis partially via modulation of the keap1/Nrf2 axis.[ ]
NASH mouse model/prevents non-alcoholic steatohepatitis by suppressing activation of the NLRP3 inflammasome[ ]
ThymolAlbino Wistar rats/cardioprotective effect against myocardial infarction by modulating oxidative stress, inflammation, and apoptosis[ ]
TriptolideMice and mouse cardiac fibroblasts/significantly inhibit the activation of NLRP3 inflammasome and show an antifibrosis effect[ ]
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Share and Cite

Câmara, J.S.; Perestrelo, R.; Ferreira, R.; Berenguer, C.V.; Pereira, J.A.M.; Castilho, P.C. Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications—A Comprehensive Overview. Molecules 2024 , 29 , 3861. https://doi.org/10.3390/molecules29163861

Câmara JS, Perestrelo R, Ferreira R, Berenguer CV, Pereira JAM, Castilho PC. Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications—A Comprehensive Overview. Molecules . 2024; 29(16):3861. https://doi.org/10.3390/molecules29163861

Câmara, José S., Rosa Perestrelo, Rui Ferreira, Cristina V. Berenguer, Jorge A. M. Pereira, and Paula C. Castilho. 2024. "Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications—A Comprehensive Overview" Molecules 29, no. 16: 3861. https://doi.org/10.3390/molecules29163861

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